This product comes packaged in a 4ml amber glass bottle and a red polypropylene cap. The end-user would receive 5mg of the 5mg pack size.
D2141
6-Diazo-5-oxo-L-norleucine
>95% (TLC), suitable for ligand binding assays
Synonyme(s) :
(S)-2-Amino-6-diazo-5-oxocaproic acid, DON
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About This Item
Formule empirique (notation de Hill):
C6H9N3O3
Numéro CAS:
Poids moléculaire :
171.15
Beilstein:
1725815
Numéro MDL:
Code UNSPSC :
12352209
ID de substance PubChem :
Nomenclature NACRES :
NA.26
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Produits recommandés
Nom du produit
6-Diazo-5-oxo-L-norleucine, crystalline
Essai
>95% (TLC)
Niveau de qualité
Forme
crystalline
Technique(s)
ligand binding assay: suitable
Couleur
light yellow
Pf
145 °C
Spectre d'activité de l'antibiotique
neoplastics
Mode d’action
enzyme | inhibits
Température de stockage
−20°C
Chaîne SMILES
N[C@@H](CCC(=O)C=[N+]=[N-])C(O)=O
InChI
1S/C6H9N3O3/c7-5(6(11)12)2-1-4(10)3-9-8/h3,5H,1-2,7H2,(H,11,12)/t5-/m0/s1
Clé InChI
YCWQAMGASJSUIP-YFKPBYRVSA-N
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Description générale
Chemical structure: amino acid derivatives
Application
6-Diazo-5-oxo-L-norleucine (DON) has been used as an inhibitor of glutamine synthetase–glutamine(amide)-2-oxoglutarate aminotransferase.[1]
Actions biochimiques/physiologiques
6-Diazo-5-oxo-L-norleucine (DON), a glutamine analogue, is used as an inhibitor to study the function, specificity and characteristics of cytidine triphosphate synthase 1(s) (CTPS1) and various glutaminase(s). DON is used to inhibit glutamine (GLN) flux between cells.
DON is associated with a number of reactions involving L-glutamine as a nitrogen source, such as nucleic acid and protein synthesis. It is known to possess anticancer activity against choriocarcinoma.[2]
DON is used to study mechanisms of glutamine utilizing enzymes such as carbamoyl phosphate synthase and cytidine triphosphate synthase.
Mention d'avertissement
Danger
Mentions de danger
Conseils de prudence
Classification des risques
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
Code de la classe de stockage
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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