D054

R(+)-SCH-23390 hydrochloride

≥98% (HPLC), solid

• Synonyme(s) : R(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
• Formule empirique (notation de Hill): C₁₇H₁₈ClNO · HCl
• Numéro CAS: 125941-87-9
• Poids moléculaire : 324.24
• Numéro MDL: MFCD00069249
• Code UNSPSC : 12352200
• ID de substance PubChem : 24277910
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: solid
• Activité optique: [α]/D +32.1°, c = 1 in DMF(lit.)
• Conditions de stockage: desiccated; protect from light
• Couleur: white
• Solubilité: H₂O: >5 mg/mL
• Chaîne SMILES: Cl[H].CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c3ccccc3
• InChI: 1S/C17H18ClNO.ClH/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12;/h2-6,9-10,15,20H,7-8,11H2,1H3;1H/t15-;/m1./s1
• Clé InChI: OYCAEWMSOPMASE-XFULWGLBSA-N
• Informations sur le gène: human ... DRD1(1812)

Description

Application

R(+)-SCH-23390 hydrochloride has been used:

• for intraperitoneal injection into experimental rats to study the role of D1 receptor in sensitization
• as a D1 receptor-selective antagonist for intracranial drug infusions
• as an antagonist of D1 receptor to study its effect on learning ability in fish

Actions biochimiques/physiologiques

R(+)-SCH-23390 hydrochloride is a selective D1 dopamine receptor antagonist. It has greater binding capacity towards 5-hydroxytryptamine 2 (5-HT2) and 5-HT1C serotonin receptor subtypes in in vitro. R(+)-SCH-23390 has a half-life of about 25 minutes after administration. It is known to possess anti-stereotypic effect and cataleptogenic effect. It also has inhibitory effect on motor activity.

Caractéristiques et avantages

This compound is featured on the Dopamine Receptors and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations légales

Sold with the permission of Schering-Plough.

Informations sur la sécurité

• Code de la classe de stockage: 13 - Non Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)