C9137

Cordycepin 5′-triphosphate sodium salt

≥95%

• Synonyme(s) : 3′-dATP, 3′-deoxy-ATP, 3′-Deoxyadenosine 5′-triphosphate
• Formule empirique (notation de Hill): C₁₀H₁₆N₅O₁₂P₃
• Numéro CAS: 71997-32-5
• Poids moléculaire : 491.18
• Numéro MDL: MFCD00057015
• Code UNSPSC : 41106305
• ID de substance PubChem : 24893135
• Nomenclature NACRES : NA.51

Propriétés

• Niveau de qualité: 200
• Pureté: ≥95%
• Forme: powder
• Poids mol.: 491.18 g/mol
• Température de stockage: −20°C
• Chaîne SMILES: [Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)CC3O
• InChI: 1S/C10H16N5O12P3.Na.H/c11-8-7-9(13-3-12-8)15(4-14-7)10-6(16)1-5(25-10)2-24-29(20,21)27-30(22,23)26-28(17,18)19;;/h3-6,10,16H,1-2H2,(H,20,21)(H,22,23)(H2,11,12,13)(H2,17,18,19);;
• Clé InChI: FRGBONDYLMUOMH-UHFFFAOYSA-N

Description

Description générale

Cordycepin (3′-deoxyadenosine) is a cytotoxic adenosine analog and a bioactive agent extracted from Cordyceps militaris. Cordycepin 5′-triphosphate is a toxic derivative of cordycepin.

Application

Cordycepin 5′-triphosphate sodium salt has been used:

• as a transcriptional inhibitor in RNA decay assay
• to inhibit polyadenylation in HEK293T cells before harvesting for in- vitro interaction studies through co-immunoprecipitation (co-Ips)
• as a positive control in in vitro assays for polymerase inhibition
• as a precursor to produce cordycepin monophosphate

Actions biochimiques/physiologiques

Cordycepin exhibits various metabolic effects by activating AMP-activated protein kinase (AMPK) in humans. Cordycepin triphosphate inhibits picornavirus polymerase-specific RNA synthesis by blocking in vitro [3H]GMP incorporation. It also retards cell growth by inhibiting RNA synthesis.

Cordycepin 5′-triphosphate is incorporated into nucleic acid by poly(A) polymerase. Because it lacks a 3′-hydroxyl group chain production it can be used for 3′-end labeling of RNA.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302 + H332,H315,H319,H335,H351
• Conseils de prudence: P202 - P301 + P312 - P302 + P352 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313
• Classification des risques: Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges