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C4116

Sigma-Aldrich

Cyclopamine hydrate

≥98% (HPLC), solid, Hedgehog signaling pathway inhibitor

Synonyme(s) :

11-deoxojervine hydrate

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About This Item

Formule empirique (notation de Hill):
C27H41NO2 · xH2O
Numéro CAS:
1217465-07-0
Poids moléculaire :
411.62 (anhydrous basis)
Code UNSPSC :
12352116
ID de substance PubChem :
24724439
Nomenclature NACRES :
NA.77

product name

Cyclopamine hydrate, ≥98% (HPLC)

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

solid

Couleur

white

Solubilité

DMSO: soluble ≥5 mg/mL
H2O: insoluble

Température de stockage

2-8°C

Chaîne SMILES 

O.C[C@@H]1CN[C@H]2[C@@H](C)[C@@]3(CC[C@H]4[C@@H]5CC=C6C[C@@H](O)CC[C@]6(C)[C@H]5CC4=C3C)O[C@@H]2C1

InChI

1S/C27H41NO2.H2O/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2;/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3;1H2/t15-,17+,19-,20-,21-,23-,24+,25-,26-,27-;/m0./s1

Clé InChI

KDAGJRDPNXDDSB-HBYCUIHISA-N

Informations sur le gène

human ... EBP(10682)

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Description générale

Cyclopamine is a steroidal alkaloid, extracted from Veratrum californicum. It prevents tumor cell growth and invasiveness in vitro and in vivo.

Application

Cyclopamine hydrate has been used:
  • as a sonic hedgehog (Shh) inhibitor in various experiments
  • to explore the effects of stress stimulation on the proliferation and differentiation of fibrochondrocytes
  • to study its influence on ocular vessel patterning

Actions biochimiques/physiologiques

Cyclopamine is a Hedgehog signaling pathway inhibitor; inhibits the growth of medulloblastoma cells.

Caractéristiques et avantages

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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