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C0399

Sigma-Aldrich

Cromolyn sodium salt

≥95%

Synonyme(s) :

Cromoglycate, Cromoglycic acid

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About This Item

Formule linéaire :
C23H14O11Na2
Numéro CAS:
15826-37-6
Poids moléculaire :
512.33
Numéro CE :
239-926-7
Numéro MDL:
MFCD00057744
Code UNSPSC :
12352200
ID de substance PubChem :
24892251
Nomenclature NACRES :
NA.77

Niveau de qualité

200

Pureté

≥95%

Forme

powder

Auteur

Sanofi Aventis

Chaîne SMILES 

[Na].OC(COc1cccc2OC(=CC(=O)c12)C(O)=O)COc3cccc4OC(=CC(=O)c34)C(O)=O

InChI

1S/C23H16O11.Na.H/c24-11(9-31-14-3-1-5-16-20(14)12(25)7-18(33-16)22(27)28)10-32-15-4-2-6-17-21(15)13(26)8-19(34-17)23(29)30;;/h1-8,11,24H,9-10H2,(H,27,28)(H,29,30);;

Clé InChI

UXMUBZWVLQEMRB-UHFFFAOYSA-N

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Description générale

Cromolyn sodium is a mast stabilizer, which is used to treat allergies. It is a bischromone and functions as a non-steroidal anti-inflammatory drug. It inhibits the release of histamines from mast cells.

Application

Cromolyn sodium salt has been used to block mast cell activation and to inhibit histamine secretion from rodent peritoneal mast cells. It has also been used to stabilize mast cells.

Actions biochimiques/physiologiques

Cromolyn blocks the release of histamine and other pro-inflammatory mediators from mast cells.

Caractéristiques et avantages

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Zuyi Weng et al.
PloS one, 7(3), e33805-e33805 (2012-04-04)
Mast cells are immune cells critical in the pathogenesis of allergic, but also inflammatory and autoimmune diseases through release of many pro-inflammatory cytokines such as IL-8 and TNF. Contact dermatitis and photosensitivity are skin conditions that involve non-immune triggers such
Osmo Kari et al.
Current allergy and asthma reports, 12(3), 232-239 (2012-03-03)
About 30% of people suffer from allergic symptoms, and 40% to 80% of them have eye symptoms. Atopic conjunctivitis is divided into seasonal allergic conjunctivitis and perennial allergic conjunctivitis. The treatment of seasonal allergic conjunctivitis is simple: antihistamines, anti-inflammatory agents
Neuropeptide Initiated Mast Cell Activation by Transcutaneous Electrical Acupoint Stimulation of Acupoint LI4 in Rats
Chen LZ, et al.
Scientific Reports, 8(1), 13921-13921 (2018)
Mast cells and histamine are triggering the NF-kappaB-mediated reactions of adult and aged perilymphatic mesenteric tissues to acute inflammation
Nizamutdinova IT, et al.
Aging (Albany. NY.), 8(11), 3065-3065 (2016)
Mehra Haghi et al.
The AAPS journal, 14(1), 79-86 (2011-12-29)
Two microparticle systems containing disodium cromoglycate (DSCG) alone or with polyvinyl alcohol (DSCG/PVA) were produced via spray drying and compared in terms of their physicochemical characteristics, aerosol performance and drug uptake across a pulmonary epithelial cell line (Calu-3), cultured under
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