B6434

Bretazenil

≥96% (HPLC), solid

• Synonyme(s) : 9H-Imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, Ro 16-6028
• Formule empirique (notation de Hill): C₁₉H₂₀N₃O₃Br
• Numéro CAS: 84379-13-5
• Poids moléculaire : 418.28
• Numéro MDL: MFCD00866987
• Code UNSPSC : 12352200
• ID de substance PubChem : 329773277
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥96% (HPLC)
• Forme: solid
• Couleur: white
• Solubilité: DMSO: 24 mg/mL; H₂O: insoluble
• Auteur: Roche
• Température de stockage: 2-8°C
• Chaîne SMILES: [H][C@@]12CCCN1C(=O)c3c(Br)cccc3-n4cnc(C(=O)OC(C)(C)C)c24
• InChI: 1S/C19H20BrN3O3/c1-19(2,3)26-18(25)15-16-13-8-5-9-22(13)17(24)14-11(20)6-4-7-12(14)23(16)10-21-15/h4,6-7,10,13H,5,8-9H2,1-3H3/t13-/m0/s1
• Clé InChI: LWUDDYHYYNNIQI-ZDUSSCGKSA-N

Description

Description générale

Bretazenil, a tetracyclic imidazocarboxylic ester, is an anxi-olytic/anticonvulsant agent. It possesses a half-life of 2.5 hours and is quickly absorbed.

Application

Bretazenil has been used to determine non-specific binding due to its affinity to bind to a variety of γ-aminobutyric acid type A (GABAA) receptor subtypes (α1-3;5). It has also been used as a GABAA receptor partial agonist in the subcutaneous Alzet minipumps to treat obese agouti?related protein (AgRP)?ablated and lean naive mice to study its effect on them.

Actions biochimiques/physiologiques

Bretazenil is capable of binding to γ-aminobutyric acid type A (GABAA) receptors that are sensitive and insensitive to diazepam. This compound possesses negligible sedative or muscle relaxant effects.

Bretazenil is a benzodiazepine partial agonist.

Caractéristiques et avantages

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This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)