B5681

Bay 11-7085

≥98% (HPLC), solid

• Synonyme(s) : (E)-3-(4-t-Butylphenylsulfonyl)-2-propenenitrile
• Formule empirique (notation de Hill): C₁₃H₁₅NO₂S
• Numéro CAS: 196309-76-9
• Poids moléculaire : 249.33
• Numéro MDL: MFCD01862602
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278273
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: solid
• Couleur: white
• Solubilité: DMSO: soluble >25 mg/mL; H₂O: insoluble
• Chaîne SMILES: CC(C)(C)c1ccc(cc1)S(=O)(=O)\C=C\C#N
• InChI: 1S/C13H15NO2S/c1-13(2,3)11-5-7-12(8-6-11)17(15,16)10-4-9-14/h4-8,10H,1-3H3/b10-4+
• Clé InChI: VHKZGNPOHPFPER-ONNFQVAWSA-N
• Informations sur le gène: human ... NFKB1(4790)

Description

Application

Bay 11-7085 has been used as:

• nuclear factor-κB inhibitor in Panc-1 cells, macrophages
• inhibitory κB kinase IKK inhibitor in human astrocytoma cells U87MGs
• phospho-p65 inhibitor human monocyte cell line THP-1

Actions biochimiques/physiologiques

Bay 11-7085 inactivates peroxisome proliferator-activated receptors γ (PPAR-γ) and increases the microtubule-associated proteins 1A/1B light chain 3B (LC3B), a marker of autophagy resulting in apoptosis in human synovial fibroblasts. It promotes apoptosis in pancreatic carcinoma and may serve as radiotherapy-sensitizing drug. BAY 11-7085 decreases B-cell lymphoma 2 (Bcl-2) by inhibiting pI-κBα (inhibitor of nuclear factor κ B kinase subunit α

Inhibits NF-κB activated expression of ICAM-1, VCAM-1, E-selectin, IL-6 and IL-8.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)