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B5016

Sigma-Aldrich

Bepridil hydrochloride

powder

Synonyme(s) :

1-Isobutoxy-2-pyrrolidino-3-(N-benzylanilino)propane hydrochloride

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About This Item

Formule empirique (notation de Hill):
C24H34N2O · HCl
Numéro CAS:
68099-86-5
Poids moléculaire :
403.00
Numéro MDL:
MFCD00065498
Code UNSPSC :
12352202
ID de substance PubChem :
24277824
Nomenclature NACRES :
NA.77

Forme

powder

Niveau de qualité

100

Auteur

Johnson & Johnson

Chaîne SMILES 

Cl.CC(C)COCC(CN(Cc1ccccc1)c2ccccc2)N3CCCC3

InChI

1S/C24H34N2O.ClH/c1-21(2)19-27-20-24(25-15-9-10-16-25)18-26(23-13-7-4-8-14-23)17-22-11-5-3-6-12-22;/h3-8,11-14,21,24H,9-10,15-20H2,1-2H3;1H

Clé InChI

JXBBWYGMTNAYNM-UHFFFAOYSA-N

Informations sur le gène

human ... CACNA1A(773) , CACNA1B(774) , CACNA1C(775) , CACNA1D(776) , CACNA1E(777) , CACNA1F(778) , CACNA1G(8913) , CACNA1H(8912) , CACNA1I(8911) , CACNA1S(779) , CACNA2D1(781) , CACNA2D2(9254) , CACNA2D3(55799) , CACNA2D4(93589) , CACNB1(782) , CACNB2(783) , CACNB3(784) , CACNB4(785) , CACNG1(786) , CACNG2(10369) , CACNG3(10368) , CACNG4(27092) , CACNG5(27091) , CACNG6(59285) , CACNG7(59284) , CACNG8(59283)

Actions biochimiques/physiologiques

Non-selective calcium channel blocker and class IV antiarrhythmic agent; inhibits Na+-Ca2+ exchange; inhibits growth of brain tumor cells in vitro.

Caractéristiques et avantages

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Chikako Shimizu et al.
Biological & pharmaceutical bulletin, 41(7), 1049-1061 (2018-05-18)
Ethanol (EtOH) dosage, frequency, and paired associative learning affect the risk of alcoholism. Recently, Spanagel et al. reported that acamprosate calcium (Acam Ca) prescribed for alcoholism exerts an anti-relapse effect via Ca. Ca is contained in foods, sometimes consumed with
Juliana Q Reimão et al.
Experimental parasitology, 128(2), 111-115 (2011-03-01)
The need for novel and efficacious drugs against neglected parasitic diseases, such as Leishmaniasis and American Trypanosomiasis, is certainly apparent. In this work, we evaluated the in vitro potential of the calcium channel blocker bepridil against Leishmania spp. and Trypanosoma
Hiroki Takanari et al.
Journal of pharmacological sciences, 115(1), 15-26 (2010-12-16)
Bepridil is effective for conversion of atrial fibrillation to sinus rhythm and in the treatment of drug-refractory ventricular tachyarrhythmias. We investigated the effects of bepridil on electrophysiological properties and spiral-wave (SW) reentry in a 2-dimensional ventricular muscle layer of isolated
Stefan Mitterreiter et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(26), 8974-8983 (2010-07-02)
The two proteases beta-secretase and gamma-secretase generate the amyloid beta peptide and are drug targets for Alzheimer's disease. Here we tested the possibility of targeting the cellular environment of beta-secretase cleavage instead of the beta-secretase enzyme itself. beta-Secretase has an
Masato Murakami et al.
Journal of cardiovascular pharmacology, 56(4), 389-395 (2010-07-14)
It has been reported that bepridil prevents ventricular fibrillation (VF) in patients with Brugada syndrome, but the comparative efficacy with and without mutation in the SCN5A gene has not been elucidated. The purpose of this study was to assess the
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