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B0385

Sigma-Aldrich

Beclomethasone

≥99%

Synonyme(s) :

9α-Chloro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione, 9α-Chloro-16β-methyl-1,4-pregnadiene-11β,17α,21-triol-3,20-dione

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About This Item

Formule empirique (notation de Hill):
C22H29ClO5
Numéro CAS:
4419-39-0
Poids moléculaire :
408.92
Numéro CE :
224-585-9
Numéro MDL:
MFCD00135614
Code UNSPSC :
12352200
ID de substance PubChem :
24278253
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥99%

Forme

powder

Auteur

GlaxoSmithKline

Température de stockage

2-8°C

Chaîne SMILES 

[H][C@]12C[C@@H](C)[C@@](O)(C(=O)CO)[C@]1(C)C[C@@H](O)[C@@]3(Cl)[C@]2([H])CCC4=CC(=O)C=C[C@@]34C

InChI

1S/C22H29ClO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12?,15?,16?,17?,19?,20?,21-,22?/m0/s1

Clé InChI

NBMKJKDGKREAPL-WOOYFSPWSA-N

Informations sur le gène

human ... CYP1A2(1544)

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Application

Beclomethasone has been used in MS−MS (mass spectrometry) methods for the analysis of β-agonists, corticosteroids, chloramphenicol and penicillins. It has also been used to find the differential response of glucocorticoids in larval regeneration model.

Actions biochimiques/physiologiques

Beclomethasone is an anti-inflammatory glucocorticoid.
It helps to decrease airway hyperresponsiveness. It also helps to regulate symptoms of asthma.

Caractéristiques et avantages

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Lydia J Finney et al.
The Journal of allergy and clinical immunology, 147(2), 510-519 (2020-10-18)
The mechanisms underlying altered susceptibility and propensity to severe Coronavirus disease 2019 (COVID-19) disease in at-risk groups such as patients with chronic obstructive pulmonary disease (COPD) are poorly understood. Inhaled corticosteroids (ICSs) are widely used in COPD, but the extent
Yufei Xie et al.
Disease models & mechanisms, 12(5) (2019-05-11)
Glucocorticoid drugs are widely used to treat immune-related diseases, but their use is limited by side effects and by resistance, which especially occurs in macrophage-dominated diseases. In order to improve glucocorticoid therapies, more research is required into the mechanisms of
A comparative analysis of changes in pMDI drug dose delivery before and after detergent coating using five antistatic valved holding chambers.
Paul Hagedoorn et al.
The journal of allergy and clinical immunology. In practice, 8(3), 1124-1125 (2019-10-09)
A comparison of beclomethasone, salmeterol, and placebo in children with asthma
Simons, FER, et al.
The New England Journal of Medicine, 337(23), 1659-1665 (1997)
Antonia Chatzopoulou et al.
Molecular and cellular endocrinology, 447, 61-70 (2017-03-01)
In humans, two splice variants of the glucocorticoid receptor (GR) exist: the canonical α-isoform, and the β-isoform, which has been shown to have a dominant-negative effect on hGRα. Previously, we have established the occurrence of a GR β-isoform in zebrafish
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