A6402

[Asn¹, Val⁵]-Angiotensin II

≥97% (HPLC)

• Formule empirique (notation de Hill): C₄₉H₇₀N₁₄O₁₁
• Numéro CAS: 20071-00-5
• Poids moléculaire : 1031.17
• Numéro MDL: MFCD00167643
• Code UNSPSC : 12352209
• ID de substance PubChem : 329770893
• Nomenclature NACRES : NA.32

Propriétés

• Niveau de qualité: 200
• Pureté: ≥97% (HPLC)
• Forme: powder
• Température de stockage: −20°C
• Chaîne SMILES: CC(C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(O)=O
• InChI: 1S/C49H70N14O11/c1-26(2)39(61-42(67)33(12-8-18-55-49(52)53)57-41(66)32(50)23-38(51)65)45(70)58-34(20-29-14-16-31(64)17-15-29)43(68)62-40(27(3)4)46(71)59-35(22-30-24-54-25-56-30)47(72)63-19-9-13-37(63)44(69)60-36(48(73)74)21-28-10-6-5-7-11-28/h5-7,10-11,14-17,24-27,32-37,39-40,64H,8-9,12-13,18-23,50H2,1-4H3,(H2,51,65)(H,54,56)(H,57,66)(H,58,70)(H,59,71)(H,60,69)(H,61,67)(H,62,68)(H,73,74)(H4,52,53,55)/t32-,33-,34-,35-,36-,37-,39-,40-/m0/s1
• Clé InChI: JYPVVOOBQVVUQV-CGHBYZBKSA-N
• Informations sur le gène: human ... AGTR1(185) ; mouse ... AGTR1(11607) ; rat ... AGTR1(24180)

Description

Amino Acid Sequence

Asn-Arg-Val-Tyr-Val-His-Pro-Phe

Description générale

Angiotensin II is a renin-angiotensin system (RAS) effector molecule, which binds to angiotensin II type-1 (AT₁R) and angiotensin II type-2 (AT₂R) receptors. The gene is located on human chromosome 3q24. Angiotensin II is mainly expressed in vessel walls, lung and kidney.

Application

[Asn¹, Val⁵]-Angiotensin II has been used:

• to study the effects of ACTH, serotonin, Ang II, carbachol and elevated [K⁺] on catecholamine and serotonin release
• to induce cyclophilin D (CypD)–dependent mitochondrial vascular superoxide (O2^{. -} ) production in hypertension
• to increase the homocysteine-induced ER stress-inducible, ubiquitin-like domain member 1 (HERPUD1) protein level in HeLa cells

Actions biochimiques/physiologiques

Angiotensin II functions as a vasoconstrictor and controls cardiovascular function. It maintains water-sodium homeostasis, modulates cellular proliferation and vascular remodelling of renin-angiotensin system. Angiotensin II has inflammatory effects.

Synthetic angiotensin agonist that is involved in the regulation of blood pressure, water consumption, and hydromineral balance in fish.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable