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A5845

Sigma-Aldrich

N-Acetyl-Leu-Glu-His-Asp-7-amido-4-trifluoromethylcoumarin

≥95% (HPLC), powder

Synonyme(s) :

Ac-LEHD-AFC

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About This Item

Formule empirique (notation de Hill):
C33H38O11N7F3
Poids moléculaire :
765.69
Numéro MDL:
MFCD01862610
Code UNSPSC :
12352209
ID de substance PubChem :
329770876
Nomenclature NACRES :
NA.32

Niveau de qualité

200

Pureté

≥95% (HPLC)

Forme

powder

Couleur

white

Solubilité

DMSO/DMF: 20 mM

Température de stockage

−20°C

Chaîne SMILES 

CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(O)=O)C(=O)Nc2ccc3c(OC(=O)C=C3C(F)(F)F)c2

InChI

1S/C33H38F3N7O11/c1-15(2)8-22(39-16(3)44)31(52)41-21(6-7-26(45)46)29(50)42-23(9-18-13-37-14-38-18)32(53)43-24(12-27(47)48)30(51)40-17-4-5-19-20(33(34,35)36)11-28(49)54-25(19)10-17/h4-5,10-11,13-15,21-24H,6-9,12H2,1-3H3,(H,37,38)(H,39,44)(H,40,51)(H,41,52)(H,42,50)(H,43,53)(H,45,46)(H,47,48)/t21-,22-,23-,24-/m0/s1

Clé InChI

HULKIXRFKRCRHD-ZJZGAYNASA-N

Informations sur le gène

human ... CARD9(64170) , CASP9(842)
mouse ... CARD9(332579) , CASP9(12371)
rat ... CARD9(64171) , CASP9(58918)

Amino Acid Sequence

NAc-Leu-Glu-His-Asp-AFC

Description générale

Amino acid derivatives of 7-amido-4-trifluoromethylcoumarin (AFC) are blue in fluorescence microscopy.

Application

N-Acetyl-Leu-Glu-His-Asp-7-amido-4-trifluoromethylcoumarin has been used to assay caspase 9 activity using a substrate-based fluorimetric detection assay

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Jianguo Li et al.
Molecular medicine reports, 10(3), 1433-1437 (2014-06-19)
There is increasing evidence that neuronal cell death occurs via extrinsic (death receptors) and intrinsic (mitochondria) pathways. Radiation induces caspase activation fundamentally via the mitochondrial pathway. Caspases are the key regulators of apoptosis. Healthy male Sprague‑Dawley rats were used in
Faezeh Attaran-Bandarabadi et al.
International journal of biological macromolecules, 101, 283-289 (2017-03-23)
Contribution of individual BIR domains to Smac antagonism is investigated. Ammonium citrate was used to activate caspase-9 and pro-caspase-9 (D315, D330/A). However, the presence of citrate resulted in autoproteolysis of pro-caspase-9 and its inhibition by XIAP BIR3, which was not
Hangting Hu et al.
Journal of controlled release : official journal of the Controlled Release Society, 306, 149-164 (2019-05-24)
Proteasome inhibitors (PIs) have markedly improved response rates as well as the survival of multiple myeloma (MM) patients over the past decade and have become an important foundation in the treatment of MM patients. Unfortunately, the majority of patients either
Shatrunajay Shukla et al.
Free radical biology & medicine, 76, 185-199 (2014-08-17)
Mammalian forkhead-box family members belonging to the 'O' category (FoxO) manipulate a plethora of genes modulating a wide array of cellular functions including cell cycle regulation, apoptosis, DNA damage repair, and energy metabolism. FoxO overexpression and nuclear accumulation have been
Qiongyu Yan et al.
DNA repair, 60, 18-28 (2017-10-25)
Non-homologous end-joining (NHEJ)-mediated repair of DNA double-strand breaks (DSBs) requires the formation of a Ku70/Ku80/DNA-PKcs complex at the DSB sites. A previous study has revealed Ku80 cleavage by caspase-3 during apoptosis. However, it remains largely unknown whether and how Ku80
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