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Key Documents

A5686

Sigma-Aldrich

Arg-Gly-Glu-Ser acetate salt

≥95% (HPLC)

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About This Item

Formule empirique (notation de Hill):
C16H29N7O8
Numéro CAS:
Poids moléculaire :
447.44
Numéro MDL:
Code UNSPSC :
12352202
ID de substance PubChem :
Nomenclature NACRES :
NA.32

Source biologique

synthetic (organic)

Niveau de qualité

Pureté

≥95% (HPLC)

Forme

powder

Température de stockage

−20°C

Chaîne SMILES 

CC(O)=O.N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(O)=O

InChI

1S/C16H29N7O8.C2H4O2/c17-8(2-1-5-20-16(18)19)13(28)21-6-11(25)22-9(3-4-12(26)27)14(29)23-10(7-24)15(30)31;1-2(3)4/h8-10,24H,1-7,17H2,(H,21,28)(H,22,25)(H,23,29)(H,26,27)(H,30,31)(H4,18,19,20);1H3,(H,3,4)/t8-,9-,10-;/m0./s1

Clé InChI

SALKOFBHHIHLSW-PUBMXKGKSA-N

Informations sur le gène

human ... FN1(2335)
mouse ... FN1(14268)
rat ... FN1(25661)

Amino Acid Sequence

Arg-Gly-Glu-Ser

Application

Arg-Gly-Glu-Ser acetate salt has been used:
  • as an integrin blocking peptide to study its effects on ciliary neurotrophic factor (CNTF) regulation in astroglioma cells
  • as a control peptide to study its effects on the binding of patient IgG to integrin αvβ6
  • as an integrin inhibitor peptide to study its effects on cell adhesion in Capsaspora owczarzaki cells

Actions biochimiques/physiologiques

Arg-Gly-Glu-Ser peptide acts as an integrin-blocking peptide.
Inhibitor of platelet aggregation

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)


Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Seong Su Kang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(27), 9277-9287 (2012-07-06)
Ciliary neurotrophic factor (CNTF) is a potent neural cytokine with very low expression in the CNS, predominantly by astrocytes. CNTF increases rapidly and greatly following traumatic or ischemic injury. Understanding the underlying mechanisms would help to design pharmacological treatments to
Gartner, T.K., et al.
Blood, 66, 305a-305a (1985)
Helena Parra-Acero et al.
Current biology : CB, 30(21), 4270-4275 (2020-08-29)
In animals, cell-matrix adhesions are essential for cell migration, tissue organization, and differentiation, which have central roles in embryonic development [1-6]. Integrins are the major cell surface adhesion receptors mediating cell-matrix adhesion in animals. They are heterodimeric transmembrane proteins that
Hiroyuki Yoshida et al.
Journal of gastroenterology, 58(8), 778-789 (2023-06-13)
Patients with primary sclerosing cholangitis (PSC) possess autoantibodies against biliary epithelial cells. However, the target molecules remain unknown. The sera of patients with PSC and controls were subjected to enzyme-linked immunosorbent assays to detect autoantibodies using recombinant integrin proteins. Integrin
Takeshi Kuwada et al.
Gastroenterology, 160(7), 2383-2394 (2021-02-15)
Ulcerative colitis is the most frequent type of inflammatory bowel disease and is characterized by colonic epithelial cell damage. Although involvement of autoimmunity has been suggested in ulcerative colitis, specific autoantigens/antibodies have yet to be elucidated. Using 23 recombinant integrin

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