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A5605

Sigma-Aldrich

Amlodipine besylate

≥98% (HPLC)

Synonyme(s) :

2-[(2-Aminoethoxy)-methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5- pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzene sulfonate, Norvasc

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About This Item

Formule empirique (notation de Hill):
C20H25ClN2O5 · C6H5SO3H
Numéro CAS:
111470-99-6
Poids moléculaire :
567.05
Numéro MDL:
MFCD00887594
Code UNSPSC :
12352200
ID de substance PubChem :
24890999
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

powder

Couleur

white

Solubilité

DMSO: ≥20 mg/mL

Chaîne SMILES 

OS(=O)(=O)c1ccccc1.CCOC(=O)C2=C(COCCN)NC(C)=C(C2c3ccccc3Cl)C(=O)OC

InChI

1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9)

Clé InChI

ZPBWCRDSRKPIDG-UHFFFAOYSA-N

Informations sur le gène

human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779)

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Application

Amlodipine besylate is a L-type calcium channel blocker which may be used for the treatment of angina pectoris and hypertension. Amlodipine also inhibits growth of human epidermoid carcinoma A431 cells and has antireproductive effects in male rats.

Actions biochimiques/physiologiques

Amlodipine is an L-type calcium channel blocker. Amlodipine belongs to a class of cardiovascular drugs, which act at the voltage gated calcium channel of the CaV1, or L-type, class. Amlodipine also has antihypertensive and antianginal effects. Its activity resides mainly in the (-)-isomer. Amlodipine inhibits growth of human epidermoid carcinoma A431 cells and has antireproductive effects in male rats.

Caractéristiques et avantages

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Dean J Kereiakes et al.
Journal of clinical hypertension (Greenwich, Conn.), 14(3), 149-157 (2012-03-01)
J Clin Hypertens (Greenwich). 2012;14:149-157. ©2012 Wiley Periodicals, Inc. Most patients with hypertension require combination therapy in order to achieve blood pressure (BP) goals. This 40-week open-label extension of the 12-week double-blind Triple Therapy With Olmesartan Medoxomil, Amlodipine, and Hydrochlorothiazide
Sheyanth Mohanakumar et al.
Lymphatic research and biology, 18(2), 156-165 (2019-08-21)
Background: The current belief is that the calcium channel blocker (CCB)-induced edema is due to a preferential arterial over
Gha-Hyun J Kim et al.
Scientific reports, 11(1), 23670-23670 (2021-12-10)
Among cases of SARS-CoV-2 infections that result in serious conditions or death, many have pre-existing conditions such as hypertension and are on renin-angiotensin-aldosterone system (RAAS) inhibitors. The angiotensin-converting-enzyme-2 (ACE2), a key protein of the RAAS pathway, also mediates cellular entry
56th EASD Annual Meeting of the European Association for the Study of Diabetes : 21-25 September 2020.
Diabetologia, 63(Suppl 1), 1-485 (2020-08-26)
Emanuele Muraca et al.
Diabetes/metabolism research and reviews, 37(3), e3389-e3389 (2020-08-02)
Hypothalamus-pituitary-adrenal (HPA) axis hyperactivity was suggested to be associated with the metabolic syndrome (MS), obesity and diabetes. The aim of this study was to test whether hypercortisolism was associated with altered glucose homeostasis and insulin resistance, hypertension and dyslipidemia in
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Articles

Calcium Channels

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Calcium Channels

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Calcium Channels

We offers many products related to calcium channels for your research needs.

Calcium Channels

We offers many products related to calcium channels for your research needs.

Chromatograms

application for HPLC

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