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A5560

Sigma-Aldrich

Anti-Water Channel Aquaporin 1 antibody produced in rabbit

IgG fraction of antiserum, lyophilized powder

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About This Item

Numéro MDL:
MFCD02262541
Code UNSPSC :
12352203
ID de substance PubChem :
24890993
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

IgG fraction of antiserum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

lyophilized powder

Espèces réactives

rat, human

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot (chemiluminescent): 1:400-1:800

Numéro d'accès UniProt

P29972

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... AQP1(358)
rat ... Aqp1(25240)

Description générale

Aquaporins are transmembrane proteins composed of 6 α helices that regulate the flow of water across the membrane. AQP1 is highly expressed on the apical membrane of kidneys.
Rabbit Anti-Water Channel Aquaporin 1 antibody binds to human and rat aquaporin 1.

Immunogène

synthetic peptide corresponding to amino acids 243-261 of human aquaporin 1 conjugated to KLH with glutaraldehyde. The epitope is identical in human, rodent, and cattle and only slightly different in frog.

Application

Rabbit Anti-Water Channel Aquaporin 1 antibody has been used for immunocytochemical assays. The product can also be used for immunohistochemistry and western blot.

Forme physique

Lyophilized from phosphate buffered saline, pH 7.4, and 0.025% sodium azide

Notes préparatoires

Isolated on immobilized Protein A

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Elisabeth Kruse et al.
Genome biology, 7(2), 206-206 (2006-03-09)
Water is the major component of all living cells, and efficient regulation of water homeostasis is essential for many biological processes. The mechanism by which water passes through biological membranes was a matter of debate until the discovery of the
R T Boyle et al.
Bulletin of environmental contamination and toxicology, 90(3), 387-390 (2013-01-01)
We used immunocytochemical and fluorometric techniques to show that gill cells of two marine invertebrates, the crab Neohelice granulata (osmoregulator) and the clam Mesodesma mactroides (osmoconformer), increase the expression of membrane transporters [Na(+)/K(+)-ATPase and aquaporin (AQP1)] after whole-animals exposure (96 h)
Kamila Foguesatto et al.
Cell biology international, 46(6), 976-985 (2022-03-09)
The physiological variations during the crustacean molting cycle have intrigued researchers for many years. Maintaining osmotic homeostasis in the face of hemolymph dilution and dealing with dynamic intracellular and extracellular calcium fluctuations are challenges these animals continuously confront. It has
Esperanza Gonzalez et al.
International journal of biological sciences, 17(8), 1864-1877 (2021-06-17)
Alcohol abuse has a high impact on the mortality and morbidity related to a great number of diseases and is responsible for the development of alcoholic liver disease (ALD). It remains challenging to detect and evaluate its severity, which is
Sidra Khan et al.
Cancers, 15(18) (2023-09-28)
Aquaporin (AQP) channels in endometrial cancer (EC) cells are of interest as pharmacological targets to reduce tumor progression. A panel of compounds, including AQP1 ion channel inhibitors (AqB011 and 5-(phenoxymethyl) furan-2-carbaldehyde, PMFC), were used to test the hypothesis that inhibition
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