A1929
Anti-Monkey IgG (whole molecule)−Alkaline Phosphatase antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonyme(s) :
Rabbit Anti-Monkey IgG (whole molecule)−AP
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About This Item
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Conjugué
alkaline phosphatase conjugate
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
secondary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Espèces réactives
baboon, monkey, marmoset
Technique(s)
direct ELISA: 1:40,000
dot blot: 1:60,000 (direct chemiluminescence assay)
Conditions d'expédition
wet ice
Température de stockage
2-8°C
Modification post-traductionnelle de la cible
unmodified
Description générale
IgG (immunoglobulin G) antibody subtype is a predominant serum immunoglobulin of the immune system. It is secreted by B cells and is found in blood and extracellular fluids. IgG is found in four subclasses IgG1, IgG2, IgG3 and IgG4. IgG has a monomeric structure.
IgGs are glycoprotein antibodies that modulate several immune responses. Serum IgG levels of rhesus monkeys are comparable to that of men, hence these monkeys are often used as models for studying immunological disorders. Thus, anti-monkey IgGs can be useful tools for the detection and localization of monkey IgGs. Anti-Monkey IgG (whole molecule)-Alkaline Phosphatase antibody binds to monkey, baboon and marmoset IgGs.
Immunogène
Purified monkey IgG (rhesus)
Application
Alkaline phosphatase-conjugated rabbit anti-monkey IgG antibody has been used as a secondary antibody in enzyme linked immunsorbent assay (ELISA) to detect the level of IgG in serum from treated marmoset monkeys. It has also been used for western blot analysis of to identify maternal IgGs in serum from Rhesus monkeys after lentiviral gene transfer.
Actions biochimiques/physiologiques
IgG antibody participates in complement fixation and opsonization.
Forme physique
Solution in 0.05 M Tris, pH 8.0, containing 1% bovine serum albumin, 1 mM MgCl2 and 15 mM sodium azide
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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S J Challacombe et al.
Immunology, 36(2), 331-338 (1979-02-01)
Rhesus monkey IgG, IgA and IgM were purified from pooled normal serum and labelled with 125I. Four monkeys were injected intravenously with approximately 50 microgram of each purified immunoglobulin containing between 25 muCi and 50 muCi of 125I. Iodination was
L Boon et al.
Journal of immunology (Baltimore, Md. : 1950), 167(5), 2942-2949 (2001-08-18)
Inhibition of CD40-CD40 ligand interaction is a potentially effective approach for treatment of autoimmune diseases, such as multiple sclerosis. We have investigated this concept with a chimeric antagonist anti-human CD40 mAb (ch5D12) in the marmoset monkey experimental autoimmune encephalomyelitis (EAE)
Stefano Colloca et al.
Science translational medicine, 4(115), 115ra2-115ra2 (2012-01-06)
Replication-defective adenovirus vectors based on human serotype 5 (Ad5) induce protective immune responses against diverse pathogens and cancer in animal models, as well as elicit robust and sustained cellular immunity in humans. However, most humans have neutralizing antibodies to Ad5
Alexander D Douglas et al.
Nature communications, 10(1), 1953-1953 (2019-04-28)
Malaria vaccine design and prioritization has been hindered by the lack of a mechanistic correlate of protection. We previously demonstrated a strong association between protection and merozoite-neutralizing antibody responses following vaccination of non-human primates against Plasmodium falciparum reticulocyte binding protein
IL-21-induced isotype switching to IgG and IgA by human naive B cells is differentially regulated by IL-4
Avery DT, et al.
Journal of Immunology, 181(3), 1767-1779 (2008)
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