A0233

AS605240

≥98% (HPLC)

• Synonyme(s) : 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione
• Formule empirique (notation de Hill): C₁₂H₇N₃O₂S
• Numéro CAS: 648450-29-7
• Poids moléculaire : 257.27
• Numéro MDL: MFCD11100415
• Code UNSPSC : 12352200
• ID de substance PubChem : 329770591
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: , faint red to orange to dark brown
• Solubilité: DMSO: 1 mg/mL, clear (warmed)
• Température de stockage: 2-8°C
• Chaîne SMILES: O=C1NC(=O)C(\S1)=C\c2ccc3nccnc3c2
• InChI: 1S/C12H7N3O2S/c16-11-10(18-12(17)15-11)6-7-1-2-8-9(5-7)14-4-3-13-8/h1-6H,(H,15,16,17)/b10-6-
• Clé InChI: SQWZFLMPDUSYGV-POHAHGRESA-N

Description

Application

AS605240 has been used:

• as a phosphatidylinositol 3-kinase (PI3K) inhibitor to study its effect on Rab5-positive early endosome (EE) vesicles.
• as a (PI3K) inhibitor to treat splenocytes for graft-versus-host disease (GVHD) induction.
• as a class 1A PI3K inhibitor to treat CD4⁺ T cells.

Actions biochimiques/physiologiques

AS605240 inhibits human recombinant phosphatidylinositol 3-kinase (PI3K) γ, α, β, and δ by competing with adenosine triphosphate (ATP). It plays a role in protecting injury following ischemic stroke. AS605240 also inhibits the activation of astrocytes under the influence of Interleukin-6 (IL-6) and its soluble receptor (sIL-6R). It reduces collagen deposition and prevents lung inflammation. AS605240 also inhibits the increase of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) expression instigated by bleomycin. It is effective in preventing pulmonary fibrosis by inhibiting the transforming growth factor β1 (TGF-β1) and T lymphocytes infiltration into lungs.

AS605240 is a potent and selective PI3Kγ inhibitor.

Caractéristiques et avantages

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphoinositide Kinases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves