71162

Naringin

≥95% (HPLC)

• Synonyme(s) : 4′,5,7-Trihydroxyflavanone 7-rhamnoglucoside, Naringenin 7-neohesperidoside, Naringenine-7-rhamnosidoglucoside, Naringoside
• Formule empirique (notation de Hill): C₂₇H₃₂O₁₄
• Numéro CAS: 10236-47-2
• Poids moléculaire : 580.53
• Numéro Beilstein : 102012
• Numéro CE : 233-566-4
• Numéro MDL: MFCD00148888
• Code UNSPSC : 12352201
• ID de substance PubChem : 57652274
• Nomenclature NACRES : NA.47

Propriétés

• Niveau de qualité: 200
• Pureté: ≥95% (HPLC)
• Forme: powder
• Activité optique: [α]20/D −80±10°, c = 1% in ethanol
• Pf: 83 °C ((181 °F ))
• Solubilité: ethanol: o.1 g/10 mL, clear to hazy, colorless to light greenish-yellow
• Chaîne SMILES: C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]2Oc3cc(O)c4C(=O)CC(Oc4c3)c5ccc(O)cc5)[C@H](O)[C@H](O)[C@H]1O
• InChI: 1S/C27H32O14/c1-10-20(32)22(34)24(36)26(37-10)41-25-23(35)21(33)18(9-28)40-27(25)38-13-6-14(30)19-15(31)8-16(39-17(19)7-13)11-2-4-12(29)5-3-11/h2-7,10,16,18,20-30,32-36H,8-9H2,1H3/t10-,16?,18+,20-,21+,22+,23-,24+,25+,26-,27+/m0/s1
• Clé InChI: DFPMSGMNTNDNHN-JJLSSNRUSA-N

Description

Application

Naringin has been used:

• as a bitter tastant to compare the behavioral response of the Drosophila larva and adult(2)
• to study its anti-inflammatory property and to determine its effect on nucleus pulposus (NP) cells(3)
• to determine its effect on bone metabolism like osteogenic differentiation, inhibition of osteoclast formation(4)

Actions biochimiques/physiologiques

Naringin can interact with signaling molecules and modulates signaling pathways. It possesses anti-inflammatory and anti-cancer activities. It also exhibits pharmacological effects on oxidative stress, bone regeneration, genetic damage, metabolic syndrome and central nervous system (CNS) diseases.

Naringin, a flavanoid in grapefruit and other citrus fruits, potently inhibits intestinal organic anion-transporting polypeptide 1A2 (OATP1A2). Grapefruit juice thereby reduces bioavailability of many pharmacological agents taken at the same time.

Autres remarques

To gain a comprehensive understanding of our extensive range of Disaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves