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Key Documents

68059

Sigma-Aldrich

FITC-CM-Dextran

average mol wt 4,000

Synonyme(s) :

FITC-CM-Dextran 4, Fluorescein isothiocyanate–Carboxymethyl–Dextran, Fluorescein isothiocyanate–Carboxymethyl–Dextran

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About This Item

Code UNSPSC :
12352116
Nomenclature NACRES :
NA.32

Source biologique

synthetic

Niveau de qualité

100

Conjugué

FITC conjugate

Forme

powder or crystals

Poids mol.

average mol wt 4,000

Composition

carboxymethyl content, 3-7%

Ampleur du marquage

0.001-0.020 mol/mol FITC glucose

Technique(s)

permeability assay: suitable

Fluorescence

λex 493 nm; λem 517 nm±5 nm in 0.1 M Tris pH 8.0

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Catégories apparentées

Description générale

FITC-CM-Dextran, also known as Fluorescein isothiocyanate–Carboxymethyl–Dextran, is an anionic fluorescent probe. The carboxyl group provides the negative charge, which improves the overall permeability of the molecule. It is supplied as a yellow powder that is freely soluble in water and electrolyte solutions. FITC-CM-Dextran is insoluble in most organic samples such as ethanol, methanol, acetone, and chloroform. FITC-CM-Dextran is manufactured by reacting selected dextran fractions with an activated carboxymethyl derivative in alkali, whereby O-carboxymethyl groups are introduced along the dextran chain.

Application

FITC-CM-dextran is used to study drug intake and delivery mechanisms in HeLa cell lines. FITC-CM-Dextran was chosen due to its high water solubility and negative charge. It is also a suitable molecule to be used in encapsulation studies for polymersomal drug delivery systems or Ps DDS. FITC-CM-Dextran is a biocompatible molecule used as a starting material in several pharmaceutical and diagnostic applications.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Yuxin Leng et al.
PloS one, 9(10), e109350-e109350 (2014-10-09)
Intra-abdominal hypertension (IAH) is known as a common, serious complication in critically ill patients. Bacterial translocation and permeability changes are considered the pathophysiological bases for IAH-induced enterogenic endotoxemia and subsequent multiorgan failure. Nevertheless, the effects of slightly elevated intra-abdominal pressures
Stefanie J Anderson et al.
Comparative medicine, 69(1), 4-15 (2018-12-14)
Here we characterized the murine dextran sulfate sodium (DSS) model of acute colitis. Specifically, we evaluated azithromycin and metronidazole treatment regimens to assess their effects on animal wellbeing, pathologic changes, barrier function, cytokine and chemokine profiles, and neutrophil migration in
Yuxin Leng et al.
Scientific reports, 6, 22814-22814 (2016-03-17)
Intra-abdominal hypertension (IAH) is a common and serious complication in critically ill patients for which there is no well-defined treatment strategy. Here, we explored the effect of IAH on multiple intestinal barriers and discussed whether the alteration in microflora provides
Carrier and dose effects on the pharmacokinetics of T-0128, a camptothecin analogue-carboxymethyl dextran conjugate, in non-tumor- and tumor-bearing rats.
Harada M, Murata J, Sakamura Y, et al.
J. Controlled Release, 71, 71-86 (2001)
Chloe Martin et al.
International journal of pharmaceutics, 511(1), 570-578 (2016-07-28)
The need to develop a greater understanding of drug delivery systems has arisen through the development of alternative biological based therapeutics. Drug delivery systems need to adapt and respond to this increasing demand for cellular transportation of highly charged species.
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