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Key Documents

339M-1

Sigma-Aldrich

Thrombomodulin (1009) Mouse Monoclonal Antibody

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100
500

Conjugué

unconjugated

Forme d'anticorps

culture supernatant

Type de produit anticorps

primary antibodies

Clone

1009, monoclonal

Description

For In Vitro Diagnostic Use in Select Regions (See Chart)

Forme

buffered aqueous solution

Espèces réactives

human

Conditionnement

vial of 0.1 mL concentrate (339M-14)
vial of 0.5 mL concentrate (339M-15)
bottle of 1.0 mL predilute (339M-17)
vial of 1.0 mL concentrate (339M-16)
bottle of 7.0 mL predilute (339M-18)

Fabricant/nom de marque

Cell Marque™

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

Isotype

IgG1κ

Contrôle

bladder, mesothelioma

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Visualisation

membranous

Informations sur le gène

human ... THBD(7056)

Catégories apparentées

Description générale

Thrombomodulin is a transmembrane glycoprotein composed of 575 amino acids (molecular weight 75 kD with natural anticoagulant properties. It is normally expressed by a restricted number of cells, such as endothelial and mesothelial cells. In addition, synovial lining and syncytiotrophoblasts of human placenta also express thrombomodulin. Several immunohistochemical endothelial markers are currently available and anti-thrombomodulin serves as another such marker, staining blood and lymphatic channels consistently. Anti-thrombomodulin has demonstrated positivity in 100% of benign vascular tumors (pyogenic granuloma and hemangioma) and 94% of malignant vascular tumors (Kaposi′s sarcoma, angiosarcoma, and epithelioid hemangioendothelioma). Hence, anti-thrombomodulin serves as a sensitive marker for lymphatic endothelial cells and their tumors. There has also been recent interest in the use of anti-thrombomodulin as an immunohiostochemical marker for mesothelial cells and malignant mesotheliomas. Anti-thrombomodulin is immunoexpressed in a variety of other tumors including squamous cell carcinomas of the lung, synovial sarcoma, transitional cell carcinoma, renal cell carcinomas and thymomas.

Qualité


IVD
IVD
IVD
RUO

Liaison

Thrombomodulin Positive Control Slides, Product No. 339S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forme physique

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Notes préparatoires

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Autres remarques

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informations légales

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Consulter la Bibliothèque de documents

Diagnostic Immunohistochemistry: Theranostic and Genomic Applications, 234-235 (2010)
R W Brown et al.
Human pathology, 24(4), 347-354 (1993-04-01)
The diagnostic distinction between malignant pleural epithelial mesothelioma and pulmonary adenocarcinoma is often difficult and partially reliant on the use of immunohistochemistry (IHC). While there are several available IHC markers preferentially expressed in adenocarcinomas compared with mesotheliomas, there are no
M A Appleton et al.
Histopathology, 29(2), 153-157 (1996-08-01)
The aim of this study was to evaluate the utility of a new commercially available antibody to thrombomodulin as an endothelial marker in formalin-fixed paraffin-embedded tissue. The expression of thrombomodulin in a variety of 50 vascular and lymphatic neoplasms and
R L Attanoos et al.
Histopathology, 29(3), 209-215 (1996-09-01)
The aim of this study was to examine the expression of three putative mesothelioma-binding antibodies, thrombomodulin, OV 632 and HBME-1 in 42 malignant mesotheliomas (27 pleural and 15 peritoneal) and 32 pulmonary adenocarcinomas. Evaluation of their use in differentiating between
C L Collins et al.
The American journal of pathology, 141(4), 827-833 (1992-10-01)
Thrombomodulin (TM) is a glycoprotein of molecular weight 75,000 kd that is normally present in restricted numbers of cells, including endothelial and mesothelial cells. In this study, the authors tested the possibility of using anti-TM to facilitate the diagnosis of
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