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Key Documents

31388

Sigma-Aldrich

Dextrane from Leuconostoc spp.

Mr ~6,000

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About This Item

Formule linéaire :
(C6H10O5)n
Numéro CAS:
9004-54-0
Numéro CE :
232-677-5
Numéro MDL:
MFCD00130935
Code UNSPSC :
12352201
Nomenclature NACRES :
NA.25

Source biologique

(Leuconostoc spp)

Niveau de qualité

200

Forme

powder

Poids mol.

Mr ~6,000

Couleur

white

Pf

483  °C ((901 °F ))

Solubilité

water: 1.5 g/10 mL, colorless to faintly yellow

Température de stockage

room temp

InChI

1S/C18H32O16/c19-1-5(21)9(23)10(24)6(22)3-31-17-16(30)14(28)12(26)8(34-17)4-32-18-15(29)13(27)11(25)7(2-20)33-18/h1,5-18,20-30H,2-4H2

Clé InChI

FZWBNHMXJMCXLU-UHFFFAOYSA-N

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Description générale

Dextran is a branched glucan composed of linear α(1→6) linked glucose units and α (1→3) link initiated branches. Dextran ranges in size from 10,000 to 150,000 Kd. Dextrans are used in many applications as volume extenders, stabilizers, matrix components, binding platforms, lubricants and physical structure components. Low molecular weight dextrans are often preferred versus high molecular weight dextrans due to their different viscosities, aggregation and permeation properties.
Dextran is an extracellular bacterial polymer of D-glucopyranose. It mostly comprises α-(1→6) linkage in the main chain and a variable number of α-(1→2), α-(1→3), α-(1→4) branched linkages.

Application

Dextran from Leuconostoc spp. has been used:
  • for the glycation of caseinate to investigate the influence of an increase in carbohydrate chain length compared to glucose
  • for the mass calibration of matrix-assisted laser desorption ionization-time of flight mass spectroscopy (MALDI-TOF) for the characterization of silver nanoparticles (AgNPs)
  • as a non-toxic stabilizer to assess the in vivo administration of tungsten trioxide(WO3) nanoparticles

Actions biochimiques/physiologiques

Dextran is used as a drug, particularly as a blood plasma volume expander. It is also useful as an adjuvant, emulsifier, carrier, and stabilizer in the food, pharmaceutical, and chemical industries. Sephadex is a cross-linked dextran that is commonly used for the separation and purification of protein. In the food industry, dextran is applicable as a thickener for jam and ice cream. It hinders the crystallization of sugar and augments moisture retention. This preserves the flavor and appearance of several food items.

Autres remarques

To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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31397

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Thomas Rath et al.
Nephron. Clinical practice, 114(1), c81-c88 (2009-11-06)
Intravenous iron supplementation is a basic principle in the therapy of haemodialysis (HD) patients with renal anaemia. In the Iron Dextran in Renal Anaemia (IDIRA) study, we analysed the efficacy of a therapy with low-molecular-weight iron dextran (LMW-ID) in stable
Eugen Sisu et al.
Rapid communications in mass spectrometry : RCM, 20(2), 209-218 (2005-12-15)
A combined methodology for obtaining at the preparative scale and characterization by nanoelectrospray ionization (nanoESI) quadrupole time-of-flight (QTOF) mass spectrometry (MS) and tandem MS (MS/MS) of linear polysaccharides modified at the reducing end is presented. Two polydisperse maltodextrins (1000 and
R J Stenekes et al.
Biomaterials, 22(13), 1891-1898 (2001-06-09)
In this paper, a novel method is presented for the preparation of dextran hydrogels and microspheres, based on crystallization. Although dextrans are known to be well soluble in water, precipitation was observed in concentrated aqueous solutions of low molecular weight
Diego Delgado et al.
Human gene therapy, 23(4), 345-355 (2012-02-03)
The goal of the present study was to analyze the potential application of nonviral vectors based on solid lipid nanoparticles (SLN) for the treatment of ocular diseases by gene therapy, specifically X-linked juvenile retinoschisis (XLRS). Vectors were prepared with SLN
Rohan P Choraghe et al.
Life (Basel, Switzerland), 11(2) (2021-02-13)
At host-pathogen contact sites with Candida albicans, Dectin-1 activates pro-inflammatory signaling, while DC-SIGN promotes adhesion to the fungal surface. We observed that Dectin-1 and DC-SIGN collaborate to enhance capture/retention of C. albicans under fluid shear culture conditions. Therefore, we devised
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Dextran and Polysaccharides Overview

Dextrans are polysaccharides with molecular weights ≥1,000 Dalton, featuring a linear backbone of α-linked d-glucopyranosyl repeating units.

Dextran and Polysaccharides Overview

Dextrans are polysaccharides with molecular weights ≥1,000 Dalton, featuring a linear backbone of α-linked d-glucopyranosyl repeating units.

Dextran and Polysaccharides Overview

Dextrans are polysaccharides with molecular weights ≥1,000 Dalton, featuring a linear backbone of α-linked d-glucopyranosyl repeating units.

Dextran and Polysaccharides Overview

Dextrans are polysaccharides with molecular weights ≥1,000 Dalton, featuring a linear backbone of α-linked d-glucopyranosyl repeating units.

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