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26430

Sigma-Aldrich

Chlortetracycline hydrochloride

suitable for fluorescence, BioReagent, from Streptomyces aureofaciens, ≥85.0% (HPLC)

Synonyme(s) :

7-Chlorotetracycline hydrochloride

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About This Item

Formule empirique (notation de Hill):
C22H23ClN2O8 · HCl
Numéro CAS:
64-72-2
Poids moléculaire :
515.34
Numéro Beilstein :
3858364
Numéro CE :
200-591-7
Numéro MDL:
MFCD00082440
Code UNSPSC :
51102829
ID de substance PubChem :
57648175
Nomenclature NACRES :
NA.85

Source biologique

Streptomyces aureofaciens

Niveau de qualité

200

Gamme de produits

BioReagent

Pureté

≥85.0% (HPLC)

Forme

powder or crystals

Couleur

faintly yellow to yellow

Pf

210-215 °C (dec.) (lit.)

Solubilité

H2O: 50 mg/mL

Adéquation

suitable for fluorescence

Spectre d'activité de l'antibiotique

Gram-negative bacteria
Gram-positive bacteria

Mode d’action

protein synthesis | interferes

Température de stockage

−20°C

Chaîne SMILES 

Cl.CN(C)[C@H]1[C@@H]2CC3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)ccc(Cl)c4[C@@]3(C)O

InChI

1S/C22H23ClN2O8.ClH/c1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(8,33)18(29)11(7)16(27)12-10(26)5-4-9(23)14(12)21;/h4-5,7-8,15,26,28-29,32-33H,6H2,1-3H3,(H2,24,31);1H/t7?,8-,15-,21-,22-;/m0./s1

Clé InChI

CBHYYLPALVVVEY-LYNLVHCPSA-N

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Description générale

Chemical structure: tetracycline

Application

Cell-permeable fluorescent probe for Ca2+ for measuring calcium flux in endoplasmic reticulum and other intracellular stores in situ.

Actions biochimiques/physiologiques

Chlortetracycline is an antibiotic produced by some strains of Streptomyces aureofaciens.
Mode of Action: Inhibits protein synthesis (elongation) by preventing binding of aminoacyl-tRNA to the 30S subunit.
Antimicrobial spectrum: Gram-positive. Less active against Gram-negative bacteria than tetracycline.
Mode of Resistance: Loss of cell wall permeability.

Conditionnement

5 g, 25 g, 100g

Qualité

Recommended for fluorescent studies of calcium signaling in cells or tissues.

Autres remarques

Keep container tightly closed in a dry and well-ventilated place.

Pictogrammes

Health hazardExclamation mark
GHS08,GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H317,H319,H335,H361fd

Classification des risques

Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

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Changlong Gou et al.
Bioresource technology, 323, 124517-124517 (2020-12-29)
Chlorotetracycline (CTC) is one of the most antibiotics present in cattle manure. In present study, three levels of CTC (0, 20 and 40 mg kg-1) were added to cattle manure composting systems to investigate its effects on the distribution of antibiotic-resistant genes
Zhanna Hakhverdyan et al.
Molecular cell, 81(1), 153-165 (2020-12-18)
Cellular processes are largely carried out by macromolecular assemblies, most of which are dynamic, having components that are in constant flux. One such assembly is the nuclear pore complex (NPC), an ∼50 MDa assembly comprised of ∼30 different proteins called
Claudia Cerella et al.
Annals of the New York Academy of Sciences, 1099, 490-493 (2007-04-21)
Many studies suggest that endoplasmic reticulum (ER) Ca2+ pool rather than cytosolic Ca2+ may play a crucial role in triggering apoptosis. In this study, we performed an image analysis of cells loaded with the fluorescent dye chlortetracycline (CTC) to in
A E Oliver et al.
Biophysical journal, 78(4), 2116-2126 (2000-03-29)
The effect of temperature on the binding equilibria of calcium-sensing dyes has been extensively studied, but there are also important temperature-related changes in the photophysics of the dyes that have been largely ignored. We conducted a systematic study of thermal
Lindsay Gillan et al.
Theriogenology, 63(2), 445-457 (2005-01-01)
Most laboratory methods used to evaluate semen quality have not correlated highly with fertilizing capacity. The discovery of a variety of fluorochromes and compounds conjugated to fluorescent probes has enabled a more widespread analysis of sperm attributes, and in conjunction
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