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Key Documents

PHR1752

Supelco

Bupropion Hydrochloride Related Compound A

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

2-(tert-Butylamino)-4′-chloropropiophenone hydrochloride, 2-(tert-butylamino)-3’-bromopiophenone hydrochloride

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About This Item

Formule empirique (notation de Hill):
C13H18ClNO · HCl
Numéro CAS:
Poids moléculaire :
276.20
Code UNSPSC :
41116107
Nomenclature NACRES :
NA.24

Qualité

certified reference material
pharmaceutical secondary standard

Niveau de qualité

Agence

traceable to USP 1078744

Famille d'API

bupropion

CofA (certificat d'analyse)

current certificate can be downloaded

Conditionnement

pkg of 30 mg

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

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Description générale

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Bupropion hydrochloride (BUP) and its derivatives belong to a chemical class of aminoketones and are known for their antidepressant abilities. BUP selectively inhibits the neuronal reabsorption of catecholamines (noradrenalin and dopamine), has minimal effect on the recapture of indolamines (serotonin) and no inhibitory effect on monoamine oxidase. It is used as the non-nicotine pharmacological therapy for combating smoking in controlled release form.
Bupropion hydrochloride (BUP) may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometric and chromatographic techniques.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Remarque sur l'analyse

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Autres remarques

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Note de bas de page

To see an example of a Certificate of Analysis for this material enter LRAA7916 in the slot below. This is an example certificate only and may not be the lot that you receive.

Produits recommandés

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


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Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Structures from powders: Bupropion hydrochloride
Maccaroni E, et al
Journal of Pharmaceutical and Biomedical Analysis, 50(2), 257-261 (2009)
Use of charge transfer complexation reaction for the spectrophotometric determination of bupropion in pharmaceuticals and spiked human urine.
Basavaiah K and Abdulrahman SAM
The Thai Journal of Pharmaceutical Sciences, 34(4), 257-261 (2010)
Determination of bupropion using liquid chromatography with fluorescence detection in pharmaceutical preparations, human plasma and human urine
Ulu ST and Tuncel M
Journal of Chromatographic Science, 50(5), 433-439 (2012)
Spectroscopic investigations on the inclusion interaction between hydroxypropyl-β-cyclodextrin and bupropion
Misiuk W and Zalewska M
Journal of Molecular Liquids, 159(3), 220-225 (2011)
Titrimetric and spectrophotometric assay of bupropion hydrochloride in pharmaceuticals using mercury (II) nitrate
Abdulaziz MA, et al.
Ecletica Quimica , 35(3), 9-16 (2010)

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