PHL80013

Cucurbitacin E

phyproof^® Reference Substance

• Synonyme(s) : α-Elaterin, α-Elaterine
• Formule empirique (notation de Hill): C₃₂H₄₄O₈
• Numéro CAS: 18444-66-1
• Poids moléculaire : 556.69
• Code UNSPSC : 41116107
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: primary reference standard
• Gamme de produits: phyproof^® Reference Substance
• Pureté: ≥95.0% (HPLC)
• Fabricant/nom de marque: PhytoLab
• Application(s): food and beverages
• Format: neat
• Température de stockage: 2-8°C
• InChI: 1S/C32H44O8/c1-17(33)40-27(2,3)13-12-23(36)32(9,39)25-21(35)15-29(6)22-11-10-18-19(14-20(34)26(38)28(18,4)5)31(22,8)24(37)16-30(25,29)7/h10,12-14,19,21-22,25,34-35,39H,11,15-16H2,1-9H3/b13-12+/t19-,21-,22+,25+,29+,30-,31+,32+/m1/s1
• Clé InChI: NDYMQXYDSVBNLL-MUYMLXPFSA-N

Description

Description générale

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG.

Actions biochimiques/physiologiques

Cucurbitacin E is a potent inhibitor of actin depolymerization. Cucurbitacin E is more active than jasplakinolide, and has a different mechanism of action, binding to a different site. Cucurbitacin E binds specifically to filamentous actin (F-actin) forming a covalent bond at residue Cys257, but not to monomeric actin (G-actin), stabilizing F-actin, without affecting actin polymerization or nucleation.

Informations légales

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P301 + P312 + P330
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable