N1636

β-Nicotinamide-adénine-dinucléotide hydrate

purified by column chromatography, ≥99%

• Synonyme(s) : β-DPN, β-NAD, Coenzyme 1, Cozymase, DPN, Diphosphopyridine nucléotide, NAD, Nadide
• Formule empirique (notation de Hill): C₂₁H₂₇N₇O₁₄P₂ · xH₂O
• Numéro CAS: 53-84-9
• Poids moléculaire : 663.43 (anhydrous basis)
• Numéro CE : 200-184-4
• Numéro MDL: MFCD00036253
• Code UNSPSC : 41106305
• eCl@ss : 39200202
• ID de substance PubChem : 24897510
• Nomenclature NACRES : NA.55

Propriétés

• Niveau de qualité: 200
• Pureté: ≥99%
• Forme: crystalline powder
• Couleur: white
• Température de stockage: −20°C
• Chaîne SMILES: NC1=NC=NC2=C1N=CN2.O[C@@H]3[C@@H](COP(O)(OP(OC[C@@H](O4)[C@@H](O)[C@@H](O)[C@H]4[N+]5=CC=CC(C(N)=O)=C5)([O-])=O)=O)OC[C@@H]3O
• InChI: 1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1
• Clé InChI: BAWFJGJZGIEFAR-NNYOXOHSSA-N

Description

Description générale

β-Nicotinamide adenine dinucleotide (NAD) is an electron carrier and a cofactor. It is ubiquitously found in the living system. NAD⁺ contains an adenylic acid and a nicotinamide-5′-ribonucleotide group linked together by a pyrophosphate moiety. In NAD⁺ complexes, the enzyme-cofactor interactions are highly conserved.

Application

β-Nicotinamide adenine dinucleotide hydrate has been used:

• to measure adenosine triphosphate (ATP) synthesis rates (kinetics measurements)
• in the reaction buffer for pyruvate kinase (PK) activity assay
• as a component of master mix for a high throughput screening

Actions biochimiques/physiologiques

β-Nicotinamide adenine dinucleotide (NAD) cycles between the oxidized (NAD⁺⁾ and reduced (NADH) forms to maintain a redox balance necessary for continued cell growth. It significantly participates in enzyme-catalyzed oxido-reduction processes and many genetic processes. It is also involved in microbial catabolism.

Accepteur d'électrons

Conditionnement

Produit conditionné en fonction du poids solide.

Autres remarques

Crystalline NAD contains less than 0.1% (w/w) residual organic solvent, is less hygroscopic and electrostatic, and is more stable at ambient temperatures than amorphous NAD.

Il s′agit de la forme courante du NAD.

Informations sur la sécurité

• Code de la classe de stockage: 13 - Non Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)