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87472

Supelco

Hydrogen chloride solution

~3 M in 1-butanol, for GC derivatization, LiChropur™

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About This Item

Numéro CAS:
7647-01-0
Numéro Beilstein :
1098214
Numéro MDL:
MFCD00011324
Code UNSPSC :
12352301
ID de substance PubChem :
329769583
Nomenclature NACRES :
NA.22

product name

Hydrogen chloride - 1-butanol solution, ~3 M in 1-butanol, for GC derivatization, LiChropur™

Qualité

for GC derivatization
LiChropur™

Niveau de qualité

100

Forme

solution

Pertinence de la réaction

reagent type: derivatization reagent
reaction type: Acylations

Concentration

~3 M in 1-butanol

Technique(s)

gas chromatography (GC): suitable

Densité

0.87 g/mL at 20 °C

Température de stockage

2-8°C

Chaîne SMILES 

Cl

InChI

1S/ClH/h1H

Clé InChI

VEXZGXHMUGYJMC-UHFFFAOYSA-N

Description générale

Acylation, an alternative to silylation, is the conversion of compounds that contain active hydrogens (-OH, -SH and -NH) into esters, thioesters, and amides through the action of a carboxylic acid or derivative. The presence of a carbonyl group adjacent to the halogenated carbons enhances electron capture detector (ECD) response. Acylation has many benefits:
  • It improves the stability of compounds by protecting unstable groups.
  • It may confer volatility on substances such as carbohydrates or amino acids, which have so many polar groups that they are non-volatile and normally decompose on heating.
  • It assists in separations not possible with underivatized compounds.
  • Compounds are detectable at very low levels with an ECD.

Hydrogen chloride-1-butanol is a reagent utilized to form fragmentation-directing derivatives for GC/MS analysis.

Application

Hydrogen chloride - 1-butanol solution has been used for butylation of amino acids during blood sample analysis for determination of ethylenediaminetetraacetic acid using mass spectrometry.

Autres remarques

Reagent for the esterification of amino acids and carnites for GC-MS analysis

Informations légales

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Pictogrammes

FlameCorrosionExclamation mark
GHS02,GHS05,GHS07

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Met. Corr. 1 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 1

Équipement de protection individuelle

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificats d'analyse (COA)

Lot/Batch Number
BCCL8269
BCCJ6881
BCCG8459
BCCF1421
BCCC2214

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Butan-1-ol anhydrous, 99.8%

Sigma-Aldrich

281549

Butan-1-ol

Chlorure d'hydrogène solution 1.0 M in diethyl ether

Sigma-Aldrich

294837

Chlorure d'hydrogène solution

Hydrogen chloride ReagentPlus®, ≥99%

Sigma-Aldrich

295426

Hydrogen chloride

Acide acétique for LC-MS LiChropur™

Supelco

5.33001

Acide acétique

Butan-1-ol suitable for HPLC, ≥99.7%

Sigma-Aldrich

34867

Butan-1-ol

M S Rashed et al.
Clinical chemistry, 43(7), 1129-1141 (1997-07-01)
Metabolic profiling of amino acids and acylcarnitines from blood spots by automated electrospray tandem mass spectrometry (ESI-MS/MS) is a powerful diagnostic tool for inborn errors of metabolism. New approaches to sample preparation and data interpretation have helped establish the methodology
Akihiro Hideno et al.
Bioresource technology, 132, 64-70 (2013-02-12)
The effects of adding trace acids in ethanol based organosolv treatment were investigated to increase the enzymatic digestibility of Japanese cypress. A high glucose yield (60%) in the enzymatic hydrolysis was obtained by treating the sample at 170 °C for
Daniely Cornélio Favarin et al.
Mediators of inflammation, 2013, 164202-164202 (2013-03-28)
Acute lung injury (ALI) is characterized by alveolar edema and uncontrolled neutrophil migration to the lung, and no specific therapy is still available. Ellagic acid, a compound present in several fruits and medicinal plants, has shown anti-inflammatory activity in several
Yan-Ling Li et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(6), 817-820 (2013-05-31)
To prepare the new traditional Chinese medicine preparation--pH-dependent brevisapin colon-specific tablets, and investigate its in vitro release, in order to discuss the feasibility of preparing colon-targeted traditional Chinese medicines. With scutellarin, the active ingredient in brevisapin, as the evaluation index
Q Miao et al.
Physical review letters, 109(23), 233905-233905 (2013-02-02)
X-ray lasing is predicted to ensue when molecules are pumped into dissociative core-excited states by a free-electron-laser pulse. The lasing is due to the population inversion created in the neutral dissociation product, and the process features self-trapping of the x-ray
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