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NMP

analytical standard

Synonyme(s) :

1-méthyl-2-pyrrolidone, N-méthyl-2-pyrrolidone, M-PYROL, NMP

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About This Item

Formule empirique (notation de Hill):
C5H9NO
Numéro CAS:
872-50-4
Poids moléculaire :
99.13
Numéro Beilstein :
106420
Numéro CE :
212-828-1
Numéro MDL:
MFCD00003193
Code UNSPSC :
41116107
ID de substance PubChem :
329768179
Nomenclature NACRES :
NA.24

product name

1-méthyl-2-pyrrolidinone, analytical standard

Qualité

analytical standard

Niveau de qualité

100

Densité de vapeur

3.4 (vs air)

Pression de vapeur

0.29 mmHg ( 20 °C)
0.99 mmHg ( 40 °C)

Pureté

≥99.9% (GC)

Température d'inflammation spontanée

518 °F

Durée de conservation

limited shelf life, expiry date on the label

Limite d'explosivité

9.5 %

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Indice de réfraction

n20/D 1.47 (lit.)
n20/D 1.470

Point d'ébullition

202 °C (lit.)
81-82 °C/10 mmHg (lit.)

Pf

−24 °C (lit.)

Densité

1.028 g/mL at 25 °C (lit.)

Application(s)

cleaning products
cosmetics
environmental
food and beverages
personal care

Format

neat

Chaîne SMILES 

CN1CCCC1=O

InChI

1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3

Clé InChI

SECXISVLQFMRJM-UHFFFAOYSA-N

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Description générale

1-Methyl-2-pyrrolidinone is a polar solvent widely used in organic chemistry and polymer chemistry. On a large scale, it finds applications in the recovery and purification of acetylenes, olefins, and diolefins, gas purification, and aromatics extraction from feedstocks.
This substance is listed on the positive list of the EU regulation 10/2011 for plastics intended to come into contact with food. Find all available reference materials for compounds listed in 10/2011 here

Application

1-Methyl-2-pyrrolidinone may be used as an eluent and extraction solvent for the extraction of soluble materials in soil samples using size exclusion chromatography.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictogrammes

Health hazardExclamation mark
GHS08,GHS07

Mention d'avertissement

Danger

Mentions de danger

H315,H319,H335,H360D

Classification des risques

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

195.8 °F - Pensky-Martens closed cup

Point d'éclair (°C)

91 °C - Pensky-Martens closed cup

Équipement de protection individuelle

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number
BCCK9544
BCCG9445
BCBZ9275
BCBT7301
BCBN7418V

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Frontiers in chemistry, 8, 149-149 (2020-03-21)
A Typha Angustifolia-like MoS2/carbon nanofiber composite as both a chemically trapping agent and redox conversion catalyst for lithium polysulfides has been successfully synthesized via a simple hydrothermal method. Cycling performance and coulombic efficiency have been improved significantly by applying the
B A Jönsson et al.
Journal of chromatography. B, Biomedical sciences and applications, 694(2), 351-357 (1997-07-04)
A method for simultaneous determination of 5-hydroxy-N-methylpyrrolidone and 2-hydroxy-N-methylsuccinimide in urine is described. These compounds are metabolites of N-methyl-2-pyrrolidone, a powerful and widely used organic solvent. 5-Hydroxy-N-methylpyrrolidone and 2-hydroxy-N-methylsuccinimide were purified from urine by adsorption to a C8 solid-phase extraction
David S Hewings et al.
Journal of medicinal chemistry, 54(19), 6761-6770 (2011-08-20)
Histone-lysine acetylation is a vital chromatin post-translational modification involved in the epigenetic regulation of gene transcription. Bromodomains bind acetylated lysines, acting as readers of the histone-acetylation code. Competitive inhibitors of this interaction have antiproliferative and anti-inflammatory properties. With 57 distinct
Chun-Wa Chung et al.
Journal of medicinal chemistry, 55(2), 576-586 (2011-12-06)
Bromodomain-containing proteins are key epigenetic regulators of gene transcription and readers of the histone code. However, the therapeutic benefits of modulating this target class are largely unexplored due to the lack of suitable chemical probes. This article describes the generation
Ajit Dhananjay Jagtap et al.
European journal of medicinal chemistry, 85, 268-288 (2014-08-05)
A series of 6-acylureido derivatives containing a 3-(pyrrol-2-ylmethylidene)indolin-2-one scaffold were synthesized as potential dual Aurora B/FLT3 inhibitors by replacing the 6-arylureido moiety in 6-arylureidoindolin-2-one-based multi-kinase inhibitors. (Z)-N-(2-(pyrrolidin-1-yl)ethyl)-5-((6-(3-(2-fluoro-4-methoxybenzoyl)ureido)-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (54) was identified as a dual Aurora B/FLT3 inhibitor (IC50 = 0.4 nM and 0.5 nM, respectively).
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