33586
Flunixin
VETRANAL®, analytical standard
Synonyme(s) :
2-[2-Methyl-3-(trifluoromethyl)phenylamino]nicotinic acid
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About This Item
Formule empirique (notation de Hill):
C14H11F3N2O2
Numéro CAS:
Poids moléculaire :
296.24
Numéro MDL:
Code UNSPSC :
41116107
ID de substance PubChem :
Nomenclature NACRES :
NA.24
Produits recommandés
Qualité
analytical standard
Niveau de qualité
Gamme de produits
VETRANAL®
Durée de conservation
limited shelf life, expiry date on the label
Technique(s)
HPLC: suitable
gas chromatography (GC): suitable
Application(s)
forensics and toxicology
pharmaceutical (small molecule)
Format
neat
Chaîne SMILES
Cc1c(Nc2ncccc2C(O)=O)cccc1C(F)(F)F
InChI
1S/C14H11F3N2O2/c1-8-10(14(15,16)17)5-2-6-11(8)19-12-9(13(20)21)4-3-7-18-12/h2-7H,1H3,(H,18,19)(H,20,21)
Clé InChI
NOOCSNJCXJYGPE-UHFFFAOYSA-N
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Catégories apparentées
Description générale
Flunixin is a potent nonsteroidal anti-inflammatory drug, primarily used as an anti-inflammatory agent and analgesic for the short-term treatment of moderate pain and inflammation in farm animals. It is also effective in inhibiting the synthesis of prostaglandins.
Flunixin is classified under the group of non-steroidal anti-inflammatory drugs (NSAIDs).
Application
Flunixin may be used as a reference standard for the determination of NSAID drug, flunixin in biological samples using high-performance liquid chromatography with diode array detection (HPLC-DAD)/particle beam mass spectrometry (PB-MS)/atmospheric pressure ionization mass spectrometry (API-MS) and gas chromatography coupled to mass spectrometry (GC-MS).
Flunixin may be used as an analytical reference standard for the determination of flunixin in:
- Bovine muscle samples by hydrophilic interaction liquid chromatography-electrospray-tandem mass spectrometry (HILIC-ESI-MS/MS) equipped with selected reaction monitoring (SRM) detection.
- Animal tissues by dispersive-solid phase extraction (d-SPE) and enhanced matrix removal for lipids (EMR-L), followed by analysis using ultra-high performance liquid chromatography-triple quadrupole or quadrupole-time-of-flight (UHPLC-QqQ or UHPLC-Q/TOF) methods in conjunction with ESI-MS/MS operating on multiple reaction monitoring (MRM) mode of detection as well as ESI-LC-MS/MS with SRM detection mode.
- Porcine muscle samples by ESI-LC-MS/MS with MRM detection mode.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
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Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
Informations légales
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
Mention d'avertissement
Danger
Mentions de danger
Conseils de prudence
Classification des risques
Acute Tox. 3 Oral
Code de la classe de stockage
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Classe de danger pour l'eau (WGK)
WGK 3
Équipement de protection individuelle
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Les clients ont également consulté
Emma Nixon et al.
Frontiers in veterinary science, 7, 82-82 (2020-03-11)
Piglet castration and tail-docking are routinely performed in the United States without analgesia. Pain medications, predominately non-steroidal anti-inflammatory drugs, are used in the EU/Canada to decrease pain associated with processing and improve piglet welfare, however, past studies have shown the
Online eluent-switching technique coupled anion-exchange liquid chromatography-ion trap tandem mass spectrometry for analysis of non-steroidal anti-inflammatory drugs in pig serum.
Chang KC, et al.
Journal of Chromatography A, 1422, 222-229 (2015)
Comparison of veterinary drug residue results in animal tissues by ultrahigh-performance liquid chromatography coupled to triple quadrupole or quadrupole-time-of-flight tandem mass spectrometry after different sample preparation methods, including use of a commercial lipid removal product.
Anumol T, et al.
Analytical and Bioanalytical Chemistry, 409(10), 2639-2653 (2017)
J E Tomlinson et al.
Equine veterinary journal, 37(1), 75-80 (2005-01-18)
Recent studies have shown that flunixin prevented recovery of equine jejunum post ischaemia. However, the use of a purported cyclooxygenase (COX)-2 preferential inhibitor, etodolac, also prevented recovery. These findings may have implications for the use of nonsteroidal anti-inflammatory drugs in
Saunders Handbook of Veterinary Drugs - E-Book (2015)
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