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07969

Sigma-Aldrich

O-(2-Aminoethyl)polyethylene glycol 3,000

Mp 3,000

Synonyme(s) :

Aminopolyethylene glycol

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About This Item

Formule linéaire :
NH2(CH2CH2O)nH
Numéro CAS:
32130-27-1
Numéro MDL:
MFCD00286223
Code UNSPSC :
12162002
ID de substance PubChem :
24846131
Nomenclature NACRES :
NA.22

Poids mol.

Mp 3,000

Niveau de qualité

100

Pertinence de la réaction

reagent type: cross-linking reagent

Extrémité Ω

hydroxyl

Extrémité α

amine

Chaîne SMILES 

[H]OCCN

Description générale

O-(2-Aminoethyl)polyethylene glycol is a heterobifunctional polyethylene glycol (hydroxyl-PEG-amine) useful in conjugation and crosslinking reactions.

Application

O-(2-Aminoethyl)polyethylene glycol has been used to synthesize PEG-poly(D,L-lactide-co-glycolide) (PEG-PLGA) conjugate for use in the synthesis of PLGA-based nanoparticles.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
BCCG6970
BCBW1386
BCBW0934
BCBV4499
BCBV5012

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Folic acid-decorated and PEGylated PLGA nanoparticles for improving the antitumour activity of 5-fluorouracil.
El-Hammadi
International Journal of Pharmaceutics, 516(1-2), 61-70 (2017)
Alan O Burts et al.
Macromolecular rapid communications, 35(2), 168-173 (2013-11-23)
This report describes the synthesis of miktoarm brush-arm star polymers (BASPs) from branched and linear norbornene-terminated macromonomers (MMs) via the brush-first ring-opening metathesis polymerization (ROMP) method. First, a polystyrene (PS)-branch-poly(lactic acid) (PLA) MM is synthesized via a combination of atom
Jeremiah A Johnson et al.
Macromolecules, 43(24), 10326-10335 (2011-05-03)
Graft-through ring-opening metathesis polymerization (ROMP) using ruthenium N-heterocyclic carbene catalysts has enabled the synthesis of bottle-brush polymers with unprecedented ease and control. Here we report the first bivalent-brush polymers; these materials were prepared by graft-through ROMP of drug-loaded polyethylene-glycol (PEG)
Jeremiah A Johnson et al.
Journal of the American Chemical Society, 133(3), 559-566 (2010-12-15)
The combination of highly efficient polymerizations with modular "click" coupling reactions has enabled the synthesis of a wide variety of novel nanoscopic structures. Here we demonstrate the facile synthesis of a new class of clickable, branched nanostructures, polyethylene glycol (PEG)-branch-azide
Molly A Sowers et al.
Nature communications, 5, 5460-5460 (2014-11-19)
Stimuli-responsive multimodality imaging agents have broad potential in medical diagnostics. Herein, we report the development of a new class of branched-bottlebrush polymer dual-modality organic radical contrast agents--ORCAFluors--for combined magnetic resonance and near-infrared fluorescence imaging in vivo. These nitroxide radical-based nanostructures
Afficher tous les articles scientifiques apparentés

Articles

Degradable Poly(ethylene glycol) Hydrogels for 2D and 3D Cell Culture

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

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