SCC201
LOX-IMVI Human Melanoma Cell Line
Human
Synonyme(s) :
LOX/IMVI, LOX IMVI, LOXIM-VI, LOXIMVI
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About This Item
Code UNSPSC :
41106514
eCl@ss :
32011203
Nomenclature NACRES :
NA.81
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product name
LOX-IMVI Human Melanoma Cell Line, LOX-IMVI human melanoma cell line is an excellent model for probing mechanisms of metastasis and for evaluation of chemotherapies.
Source biologique
human
Technique(s)
cell culture | mammalian: suitable
Description générale
Malignant melanoma is highly treatable when diagnosed early, but can spread rapidly if undetected, resulting in the highest mortality among skin cancer types. Lymph nodes and lungs are the most common sites of melanoma metastases , and because of the poor prognosis and limited efficacy of current treatments, metastatic melanoma has generated intense interest as a target for therapeutic intervention.
The LOX-IMVI human melanoma cell line is widely used as an in vitro model system to study tumor metastasis and to test for chemosensitivity to potential anti-cancer compounds. LOX-IMVI cells exhibit a tendency to form lung metastases in nude mice independent of the inoculation site , and mortality of experimental animals is observed within 3-5 weeks of LOX-IMVI cell injection . LOX-IMVI cells are genetically characterized by lack of the Y chromosome and trisomy 7 , and are heterozygous for the BRAF V600E melanoma driver mutation . LOX-IMVI cells are amelanotic and express the human melanoma marker GD3 ganglioside, a factor in metastatic potential of malignant melanoma .
Source:
The LOX-IMVI human melanoma cell line was established from a subcutaneous xenograft in nude mice from a lymph node metastasis of a 58-year-old Caucasian male patient with malignant amelanotic melanoma .
Source:
The LOX-IMVI human melanoma cell line was established from a subcutaneous xenograft in nude mice from a lymph node metastasis of a 58-year-old Caucasian male patient with malignant amelanotic melanoma .
Description de la lignée cellulaire
Cancer Cells
Application
LOX-IMVI human melanoma cell line is an excellent model for probing mechanisms of metastasis and for evaluation of chemotherapies.
Research Category
Cancer
Cancer
This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
Qualité
• Each vial contains ≥ 1X10⁶ viable cells.
• Cells are tested negative for HPV-16, HPV-18, Hepatitis A, B, C, and HIV-1 & 2 viruses by PCR.
• Cells are verified to be of human origin and negative for inter-species contamination from rat, mouse, chinese hamster, Golden Syrian hamster, and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are negative for mycoplasma contamination.
• Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.
• Cells are tested negative for HPV-16, HPV-18, Hepatitis A, B, C, and HIV-1 & 2 viruses by PCR.
• Cells are verified to be of human origin and negative for inter-species contamination from rat, mouse, chinese hamster, Golden Syrian hamster, and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are negative for mycoplasma contamination.
• Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.
Stockage et stabilité
Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Jana Jandova et al.
Molecular carcinogenesis, 61(6), 603-614 (2022-04-14)
Molecularly targeted therapeutics have revolutionized the treatment of BRAFV600E -driven malignant melanoma, but the rapid development of resistance to BRAF kinase inhibitors (BRAFi) presents a significant obstacle. The use of clinical antimalarials for the investigational treatment of malignant melanoma has
Ogechi N Ikediobi et al.
Molecular cancer therapeutics, 5(11), 2606-2612 (2006-11-08)
The panel of 60 human cancer cell lines (the NCI-60) assembled by the National Cancer Institute for anticancer drug discovery is a widely used resource. The NCI-60 has been characterized pharmacologically and at the molecular level more extensively than any
James J Miller et al.
Scientific reports, 11(1), 8213-8213 (2021-04-17)
Plasmin is the key enzyme in fibrinolysis. Upon interaction with plasminogen activators, the zymogen plasminogen is converted to active plasmin. Some studies indicate plasminogen activation is regulated by cation-independent mannose 6-phosphate receptor (CI-MPR), a protein that facilitates lysosomal enzyme trafficking
AP-1 transcription factor network explains diverse patterns of cellular plasticity in melanoma cells.
Comandante-Lou, et al.
Cell Reports, 40, 111147-111147 (2022)
I Kjønniksen et al.
Cancer research, 49(18), 5148-5152 (1989-09-15)
Experimental lung metastases regularly developed in athymic Han:rnu/rnu Rowett rats after i.v. injection of LOX human malignant melanoma cells. When 5 x 10(5) tumor cells were injected into 4-week-old rats, 89% of the animals died of lung tumors, with a
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