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Key Documents

MAB4148

Sigma-Aldrich

Anti-MRP2 Antibody, clone M2 I-4

culture supernatant, clone M2 I-4, Chemicon®

Synonyme(s) :

cMOAT

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

300

Forme d'anticorps

culture supernatant

Type de produit anticorps

primary antibodies

Clone

M2 I-4, monoclonal

Espèces réactives

human

Fabricant/nom de marque

Chemicon®

Technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

Isotype

IgG1

Numéro d'accès NCBI

NM_000392.2

Numéro d'accès UniProt

Q92887

Conditions d'expédition

wet ice

Informations sur le gène

human ... ABCC2(1244)

Spécificité

This antibody reacts with an internal epitope of MRP2, a 190-200 kDa transmembrane protein previously known as the canalicular multi-organic anion transporter (cMOAT). MRP2 is a member of the MRP family of multidrug resistance related proteins, and MRP2 overexpression has been observed in a subset of cisplatin resistant cell lines. This antibody does not cross-react with the human MDR1, MRP1, MRP3 or MRP5 gene products.

Immunogène

Fusion protein of MRP2 containing aa 215-310 of the protein.

Application

This Anti-MRP2 Antibody, clone M2 I-4 is validated for use in WB, IC, IH for the detection of MRP2.
Western blotting: 1:20 - 1:50 with anti-mouse HRP

Immunocytochemistry: 1:20 - 1:50 on acetone fixed cytospin preparations

Immunohistochemistry: 1:20 on acetone fixed frozen tissue sections

Optimal working dilutions must be determined by end user.

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informations légales

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Michael J Hafey et al.
Drug metabolism and disposition: the biological fate of chemicals, 48(11), 1147-1160 (2020-09-19)
Hepatocellular accumulation of bile salts by inhibition of bile salt export pump (BSEP/ABCB11) may result in cholestasis and is one proposed mechanism of drug-induced liver injury (DILI). To understand the relationship between BSEP inhibition and DILI, we evaluated 64 DILI-positive
Päivi Myllynen et al.
Toxicology and applied pharmacology, 232(2), 210-217 (2008-08-06)
We have studied the role of ATP binding cassette (ABC) transporters in fetal exposure to carcinogens using 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) a known substrate for ABC transporters as a model compound. In perfusion of human term placenta, transfer of (14)C-PhIP (2 microM)
M Kummu et al.
Placenta, 33(10), 859-865 (2012-08-16)
Heavy metals such as cadmium, lead and methylmercury are known to be neurotoxic to developing fetus. ABCG2 which is an efflux transporter located in the maternal facing membranes of human placenta protects fetus from xenobiotics by transferring compounds from syncytiotrophoblast
Tobacco carcinogen NNK transporter MRP2 regulates CFTR function in lung epithelia: implications for lung cancer.
Chunying Li,John D Schuetz,Anjaparavanda P Naren
Cancer letters null
C C Paulusma et al.
Science (New York, N.Y.), 271(5252), 1126-1128 (1996-02-23)
The human Dubin-Johnson syndrome and its animal model, the TR(-) rat, are characterized by a chronic conjugated hyperbilirubinemia. TR(-) rats are defective in the canalicular multispecific organic anion transporter (cMOAT), which mediates hepatobiliary excretion of numerous organic anions. The complementary
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