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Key Documents

MAB3418B

Sigma-Aldrich

Anti-MAP2 Antibody, clone AP20, Biotin Conjugated

clone AP20, from mouse, biotin conjugate

Synonyme(s) :

Microtubule-associated protein 2, MAP-2, MAP2

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100

Conjugué

biotin conjugate

Forme d'anticorps

purified antibody

Type de produit anticorps

primary antibodies

Clone

AP20, monoclonal

Espèces réactives

rat

Réactivité de l'espèce (prédite par homologie)

bovine (immunogen homology), mouse (based on 100% sequence homology), chicken (based on 100% sequence homology), human (based on 100% sequence homology)

Technique(s)

immunocytochemistry: suitable

Isotype

IgG

Numéro d'accès UniProt

Q0IIA8

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

chicken ... Map2(424001)
human ... MAP2(4133)
mouse ... Map2(17756) , Map2(281294)
rat ... Map2(25595)

Description générale

The microtubule-associated protein 2 (MAP-2) is an abundant neuronal cytoskeletal protein that binds to tubulin, stabilizes microtubules (Herzog and Weber, 1978), and is an excellent marker for neurons. MAP-2 is essential for the development and maintenance of neuronal morphology (Matus, 1991). Three primary isoforms of MAP-2, the high molecular weight MAP2a and MAP2b, and the low molecular weight MAP2c (resulting from alternate splicing of the MAP2 gene), have been identified in neurours. (Chung et al., 1996). The low molecular weight isoform, MAP2c, is expressed in developing brain and is down-regulated during brain maturation, whereas the high molecular weight MAP2b is expressed in both developing and adult brain. The MAP2a appears only after brain maturation (Tucker, 1990). All these forms bind to microtubules through a domain near the carboxyl terminus that contains either three or four similar repeats of a 31-amino-acid motif (Lewis et al., 1988). MAP-2 together with MAP-4 and tau proteins belong to the family of thermostable proteins associated with microtubules.

Immunogène

Bovine brain microtubule protein

Application

Anti-MAP2 Antibody, clone AP20, Biotin Conjugated is an antibody against MAP2 for use in ICC.
Immunocytochemistry Analysis: A 1:25 dilution from a representative lot detected MAP2 in rat E18 primary cortex cells.

Qualité

Evaluated by Immunohistochemistry in rat cortex tissue.

Immunohistochemistry Analysis: A 1:25 dilution of this antibody detected MAP2 in rat cortex tissue.

Description de la cible

The unconjugated parent antibody (Cat. No. MAB3418) has an observed molecular weight at ~230 kDa

Forme physique

Purified mouse monoclonal IgG conjugated to Biotin in PBS with 0.1% sodium azide and 15 mg/mL BSA.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Scott D Bury et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 22(19), 8597-8606 (2002-09-28)
In humans and other animals, sufficient unilateral damage to the sensorimotor cortex can cause impairments in the opposite forelimb and the development of a hyper-reliance on the nonimpaired limb. This hyper-reliance is adaptive to the extent that it contributes to

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