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CBL1337

Sigma-Aldrich

Anti-PECAM-1 Antibody, clone 390

clone 390, Chemicon®, from rat

Synonyme(s) :

CD31

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

rat

Niveau de qualité

100

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

390, monoclonal

Espèces réactives

mouse

Fabricant/nom de marque

Chemicon®

Technique(s)

flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable

Isotype

IgG2aκ

Numéro d'accès NCBI

NM_000442.3

Numéro d'accès UniProt

P16284

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... PECAM1(5175)

Description générale

CD31, also known as platelet endothelial cell adhesion molecule 1 (PECAM1) is a type I integral membrane glycoprotein, and a member of the immunoglobulin superfamily of cell surface receptors. PECAM-1 is constitutively expressed on the surface of endothelial cells where it is concentrated at cell junctions. PECAM-1 is also expressed at low levels on all leukocytes and platelets. Homotypic interaction of CD31 is important in cell-cell interaction, cell-matrix interaction and signal transduction.

Application

Anti-PECAM-1 Antibody, clone 390 is an antibody against PECAM-1 for use in FC, IH & IP.
Flow Cytometry: 1 μg/10e6 cells.

Immunohistochemistry: acteone fixed frozen tissue sections

Immunoprecipitation

Blocking of cell adhesion: CBL1337 inhibits aggregation of L cells transfected with a variant form of CD31 (DeLisser, 1993)

Optimal working dilutions must be determined by the end user.

Forme physique

Format: Purified
Protein A Purified mouse immunoglobulin in 100mM borate buffered saline, pH 8.0, containing no preservative.

Remarque sur l'analyse

Control
Jurkat and Raji cells, tonsil tissue

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informations légales

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Pictogrammes

Health hazard
GHS08

Mention d'avertissement

Danger

Mentions de danger

H360FD

Classification des risques

Repr. 1B

Code de la classe de stockage

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Katsuhiro Hayashi et al.
The Journal of surgical research, 140(2), 165-170 (2007-04-10)
Angiogenesis is a critical step in tumor growth, progression, and metastasis. Soft tissue and bone sarcoma are resistant to most therapeutic approaches. Angiogenesis of these tumors may be an effective target. We hypothesized that we could inhibit tumor growth by
Targeting Vascular Amyloid in Arterioles of Alzheimer Disease Transgenic Mice With Amyloid ? Protein Antibody-Coated Nanoparticles.
Poduslo JF, Hultman KL, Curran GL, Preboske GM, Chamberlain R, Marjanska M, Garwood M et al.
Journal of Neuropathology and Experimental Neurology null
Varun Venkataramani et al.
Cell, 185(16), 2899-2917 (2022-08-02)
Glioblastomas are incurable tumors infiltrating the brain. A subpopulation of glioblastoma cells forms a functional and therapy-resistant tumor cell network interconnected by tumor microtubes (TMs). Other subpopulations appear unconnected, and their biological role remains unclear. Here, we demonstrate that whole-brain
Minshu Wang et al.
ESC heart failure, 8(2), 1427-1437 (2021-01-30)
Endothelial activation and inflammatory cell infiltration have important roles in the development of cardiac fibrosis induced by renin-angiotensin system activation. NADPH oxidases (Nox proteins) are expressed in endothelial cells (ECs) and alter their function. Previous studies indicated that Nox2 in
Simone P Niclou et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 22(9), 3120-3128 (2008-05-23)
A NOD/Scid mouse expressing enhanced green fluorescent protein (eGFP) is described, in which human and mouse tumors marked with red fluorescent protein can be established in vivo, both at subcutaneous and orthotopic locations. Using light microscopy as well as multiphoton
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