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Merck
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Key Documents

AB1570W

Sigma-Aldrich

Anti-GABA Transporter-1 Antibody

Chemicon®, from rabbit

Synonyme(s) :

GAT-1

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Produit purifié par

affinity chromatography

Espèces réactives

rabbit, mouse, monkey, human, rat, feline

Fabricant/nom de marque

Chemicon®

Technique(s)

immunohistochemistry: suitable
western blot: suitable

Numéro d'accès NCBI

Numéro d'accès UniProt

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... SLC6A1(6529)

Spécificité

Recognizes GABA Transporter-1 (GAT-1), C-terminus. No cross-reactivity to the C-termini of other transmitter transporters detected.

Immunogène

Rat GAT-1, C-terminus (aa 588-599)

Application

Anti-GABA Transporter-1 Antibody detects level of GABA Transporter-1 & has been published & validated for use in IH & WB.
Western blotting: 1:200-1:500 (67 kDa)

Immunohistochemistry

Optimal working dilutions must be determined by the end user.

Description de la cible

67 kDa

Forme physique

Affinity Purified antibody. Lyophilized from 0.1 M PBS with 1% BSA and 0.1% sodium azide. Reconstitute with 100 μL of sterile distilled water.

Stockage et stabilité

Maintain lyophilized material at 2–8°C for up to 12 months. Maintain reconstituted materialat -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informations légales

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Pictogrammes

Exclamation mark

Mention d'avertissement

Warning

Mentions de danger

Classification des risques

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Chronic 3

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3


Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Brain-derived neurotrophic factor (BDNF) enhances GABA transport by modulating the trafficking of GABA transporter-1 (GAT-1) from the plasma membrane of rat cortical astrocytes.
Vaz, SH; J?rgensen, TN; Cristov?o-Ferreira, S; Duflot, S; Ribeiro, JA; Gether, U; Sebasti?o, AM
The Journal of Biological Chemistry null
Roberta Celli et al.
Current neuropharmacology, 21(1), 105-118 (2022-05-18)
Previous studies suggest that different metabotropic glutamate (mGlu) receptor subtypes are potential drug targets for treating absence epilepsy. However, no information is available on mGlu3 receptors. To examine whether (i) changes of mGlu3 receptor expression/signaling are found in the somatosensory
Roberta Celli et al.
Neuropharmacology, 178, 108240-108240 (2020-08-10)
Previous studies have shown that injection of the mGlu5 receptor positive allosteric modulator (PAM) VU0360172 into either the thalamus or somatosensory cortex markedly reduces the frequency of spike-and-wave discharges (SWDs) in the WAG/Rij model of absence epilepsy. Here we have
Elena E Bagley et al.
Neuron, 45(3), 433-445 (2005-02-08)
Adaptations in neurons of the midbrain periaqueductal gray (PAG) induced by chronic morphine treatment mediate expression of many signs of opioid withdrawal. The abnormally elevated action potential rate of opioid-sensitive PAG neurons is a likely cellular mechanism for withdrawal expression.
Jaime M Hatcher et al.
Experimental neurology, 204(2), 619-630 (2007-02-13)
Numerous epidemiological studies have shown an association between pesticide exposure and an increased risk of developing Parkinson's disease (PD). Here, we provide evidence that the insecticide dieldrin causes specific oxidative damage in the nigrostriatal dopamine (DA) system. We report that

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