616400-M

Tranilast

An anthranilic acid analog that acts as a potent inhibitor of VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis.

• Synonyme(s) : Tranilast, N-(3ʹ,4ʹ-Dimethoxycinnamoyl)anthranilic Acid
• Formule empirique (notation de Hill): C₁₈H₁₇NO₅
• Numéro CAS: 53902-12-8
• Poids moléculaire : 327.33
• Numéro MDL: MFCD00864787
• Code UNSPSC : 51111800

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: pale yellow
• Solubilité: DMSO: 200 mg/mL
• Température de stockage: −20°C
• InChI: 1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+
• Clé InChI: NZHGWWWHIYHZNX-CSKARUKUSA-N

Description

Description générale

An anthranilic acid analog that acts as a potent inhibitor of VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis. Also has antiallergic, anti-inflammatory, and antiproliferative properties. Induces Ca²⁺ mobilization in vascular smooth muscle.

An anthranilic acid analog that acts as a potent inhibitor of VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis. Inhibits VEGF- and PMA-stimulated PKC activity in retinal capillary endothelial cells without affecting the VEGF binding or VEGF receptor phosphorylation. Also has antiallergic, anti-inflammatory, and antiproliferative properties. Induces Ca²⁺ mobilization in vascular smooth muscle.

Actions biochimiques/physiologiques

Primary Target
VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis

Avertissement

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C).

Autres remarques

Koyama, S., et al. 1999. Br. J. Pharmacol. 127, 537.
Isaji, M., et al. 1998. Life Sci. 63, PL71.
Isaji, M., et al. 1997. Br. J. Pharmacol. 122, 1061.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable