Produced by the anaerobic bacillus Clostridium tetani. Tetanus toxin is one of the deadliest toxins known. Composed of two polypeptide chains joined by a single interchain disulfide bond. The heavy chain (100 kDa) participates in binding to the nerve terminals, internalization, retrograde axonal transport, and membrane translocation of the light chain (50 kDa) into the neuronal cytosol. The light chain inhibits neurotransmitter release after reduction of the disulfide bridge.
Tetanus toxin is produced by Clostridium tetani. Composed of a 100 kDa heavy and a 50 kDa light chain joined by a single interchain disulfide bond.
Actions biochimiques/physiologiques
Binds GT1b ganglioside in a hemagglutination assay
Primary Target Tetanus toxin is one of the deadliest toxins known
Product does not compete with ATP.
Avertissement
Toxicity: Highly Toxic (H)
Reconstitution
Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C.
Please refer to the vial label for lot-specific reconstitution volume.
Remarque sur l'analyse
Single band by SDS-PAGE
Autres remarques
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Montecucco, C., et al. 1994. FEBS Lett. 346, 92. Wellhöner, H.H., et al. 1987. J. Biol. Chem. 262, 17374.
Informations légales
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Classe de danger pour l'eau (WGK)
WGK 3
Certificats d'analyse (COA)
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