5.08438

Lamellipodial Growth Promoter, C8N6 BPA Polyamine

• Synonyme(s) : Lamellipodial Growth Promoter, C8N6 BPA Polyamine, Actin Regulator, C8N6 BPA polyamine, Lamellipodial Enhancer, C8N6 BPA polyamine
• Formule empirique (notation de Hill): C₂₀H₄₈N₆ · 6HCl
• Numéro CAS: 870087-09-5
• Poids moléculaire : 591.40
• Code UNSPSC : 12352116
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥95% (NMR)
• Niveau de qualité: 100
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: off-white
• Solubilité: water: 100 mg/mL; DMSO: 50 mg/mL
• Température de stockage: 2-8°C

Description

Description générale

A cell-permeable, fast acting, branched polyamine (C8N6) that specifically induces the growth of actin-enriched lamellipodia within minutes (at ~ 10-100 µM) without the need for serum cofactors . Its effects are more pronounced on the edges of cells that exhibit lamellipodial activity before any treatment. Enhances nucleation by capping protein and thereby facilitates the initiation of filament branching at the lamellipodium tip. Does not affect actin polymerization in cells pre-treated with depolymerizing agents. Does not affect the survival or death of tumor cells even at higher concentration (1 mM). The assembly of actin appears to be more distinct at physiological ionic concentrations. The Cy3 conjugated version is also available (Cat. No. xxxx?)

A cell-permeable, fast acting, branched polyamine (C8N6) that specifically induces the growth of actin-enriched lamellipodia within minutes (at ~10-100 µM) without the need for serum cofactors . Its effects are more pronounced on the edges of cells that exhibit lamellipodial activity before any treatment. Enhances nucleation by capping protein and thereby facilitates the initiation of filament branching at the lamellipodium tip. Does not affect actin polymerization in cells pre-treated with depolymerizing agents. Does not affect the survival or death of tumor cells even at higher concentration (1 mM). The assembly of actin appears to be more distinct at physiological ionic concentrations.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Actions biochimiques/physiologiques

Cell permeable: yes

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Autres remarques

Nedeva, I., et al. 2013. Nat. Commun.4, 2165.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable