5.08225

(Z)-4-Hydroxytamoxifen

≥99% (HPLC), liquid, estrogen receptor modulator, Calbiochem

• Synonyme(s) : InSolution Tamoxifen, 4-Hydroxy-, ( Z)-, ( Z)-4-(1-(4-(Dimethylaminoethoxy)phenyl)-2-phenyl-1-butenyl)phenol, ( Z)-4-(1-(4-(2-(Dimethylamino)ethoxy)phenyl)-2-phenylbut-1-enyl)phenol, (Z)-4-Hydroxytamoxifen, (Z)-4-OH-TAM, trans-4-Hydroxytamoxifen
• Formule empirique (notation de Hill): C₂₆H₂₉NO₂
• Numéro CAS: 68047-06-3
• Poids moléculaire : 387.51
• Numéro MDL: MFCD00278780
• Code UNSPSC : 51111800
• Nomenclature NACRES : NA.77

Propriétés

• product name: (Z)-4-Hydroxytamoxifen, InSolution, ≥99%
• Niveau de qualité: 100
• Pureté: ≥99% (HPLC)
• Forme: liquid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• Température de stockage: −70°C
• InChI: 1S/C26H29NO2/c1-4-25(20-10-14-23(28)15-11-20)26(21-8-6-5-7-9-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-
• Clé InChI: DODQJNMQWMSYGS-QPLCGJKRSA-N

Description

Description générale

A 10 mM (2 mg/516 µL) sterile-filtered solution of (Z)-4-Hydroxytamoxifen in ethanol.

A cell-permeable, active metabolite of Tamoxifen (Cat. No. 579000) that acts as a potent inhibitor of PKC. It is more potent than the parent compound and inhibits PKC by modifying its catalytic domain.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
Estrogen receptor

Avertissement

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Forme physique

A 10 mM (2 mg/516 µL) sterile-filtered solution of (Z)-4-Hydroxytamoxifen (Cat. No. 579002) in EtOH.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only anhydrous, 200 proof ethanol for further dilutions.

Autres remarques

Gundimeda, U., et al. 1996. J. Biol. Chem.271, 13504.
Ye, Q. and Bodell, W.J. 1996. Carcinogenesis17, 1747.
Laser, R., et al. 1985. Eur. J. Cancer Clin. Oncol.21, 985.
Jordan, V.C., et al. 1978. J. Toxicol. Environ. Health4, 364.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS02,GHS07,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H225 - H319 - H350 - H360FD - H412
• Conseils de prudence: P202 - P210 - P233 - P273 - P305 + P351 + P338 - P308 + P313
• Classification des risques: Aquatic Chronic 3 - Carc. 1B - Eye Irrit. 2 - Flam. Liq. 2 - Repr. 1B
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): 55.4 °F
• Point d'éclair (°C): 13 °C