5.06415

SB-269970 Hydrochloride

• Synonyme(s) : SB-269970 Hydrochloride, 5-HT7 Serotonin receptor antagonist, SB-269970, SB 26,970, SB 26,970
• Formule empirique (notation de Hill): C₁₈H₂₈N₂O₃S · xHCl
• Numéro CAS: 261901-57-9
• Poids moléculaire : 352.49 (free base basis)
• Numéro MDL: MFCD03788020
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Niveau de qualité: 100
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: off-white
• Solubilité: DMSO: soluble
• Température de stockage: 2-8°C
• InChI: 1S/C18H28N2O3S.ClH/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18;/h2,5-6,14-16,21H,3-4,7-13H2,1H3;1H/t16-;/m1./s1
• Clé InChI: XQCJOYZLWFNDIO-PKLMIRHRSA-N

Description

Description générale

A selective 5-HT₇ receptor antagonist. Extremely potent in vivo and in vitro. Chronic or acute (even single dose) administration of SB269970 induces functional desensitization of the 5-HT₇ receptor system, which precedes changes in the receptor density. This mechanism may be responsible for the rapid antidepressant-like effect of the 5-HT₇ antagonist in animal models. SB-269970 is an analogue of SB-258719 and has been shown to have at least 100 fold selectivity versus all other 5-HT receptor subtypes except the human 5-HT_5A receptor (pKi values are 8.9, 7.2 and 6.0 for 5-HT_7A, 5-HT_5A and 5-HT_1B).

Actions biochimiques/physiologiques

Primary Target
5-HT₇

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Tokarski, K. et al. 2012. Pharmacol. Rep.64, 256.
Thomas. D. R. et al. 2000. Br. J. Pharmacol.130, 409.
Lovell, P. J. et al. 2000. J. Med. Chem.43, 342.

Forbes, I. T. et al. 1998. J. Med. Chem.41, 655.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable