444251-M

MMP-2/MMP-9 Inhibitor III

The MMP-2/MMP-9 Inhibitor III controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Synonyme(s) : MMP-2/MMP-9 Inhibitor III
• Formule empirique (notation de Hill) : C₅₂H₇₁N₁₃O₁₄S₂
• Poids moléculaire : 1166.33
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥97% (HPLC)
• Forme: lyophilized solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic)
• Couleur: white
• Solubilité: water: 5 mg/mL
• Température de stockage: −20°C

Description

Description générale

A cyclic peptide that acts as a potent inhibitor of MMP-2 (gelatinase A; IC₅₀ = 10 µM) and MMP-9 (gelatinase B; IC₅₀ = 10 µM). Inhibits the migration of human endothelial cells and tumor cells, and prevents tumor growth and invasion in animal models.

A hydrophobic cyclic peptide that acts as a potent inhibitor of MMP-2 and MMP-9 (IC₅₀ = 10 µM). Inhibits the migration of human endothelial cells and tumor cells, and prevents tumor growth and invasion in animal models. Also, phage that display this peptide specifically targets angiogenic blood vessels in vivo.

Actions biochimiques/physiologiques

Target IC₅₀: 10 µM against MMP-2 and MMP-9

Autres remarques

H-Cys¹-Thr-Thr-His-Trp-Gly-Phe-Thr-Leu-Cys¹⁰-OH (cyclic: 1→ 10)

Medina, O.P., et al. 2001. Cancer Res.61, 3978.
Koivunen, E., et al. 1999. Nat. Biotechnology 17, 768.

Informations légales

Sold under license of U.S. Patent 6,624,144.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Toxicity: Standard Handling (A)

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable