369075

Guanidine Hydrochloride

ULTROL^® Grade, ≥99% (titration), protein denaturant for purification of proteins, nucleic acids, and mRNA

• Synonyme(s) : Guanidinium chloride
• Formule empirique (notation de Hill): CH₅N₃ · xHCl
• Numéro CAS: 50-01-1
• Poids moléculaire : 59.07 (free base basis)
• Numéro MDL: MFCD00013026
• Code UNSPSC : 12352107
• Nomenclature NACRES : NA.25

Propriétés

• Niveau de qualité: 100
• Pureté: ≥99% (titration)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic)
• Couleur: white
• Solubilité: ethanol: soluble; water: soluble
• Conditions d'expédition: ambient
• Température de stockage: 15-25°C
• InChI: 1S/CH5N3.ClH/c2-1(3)4;/h(H5,2,3,4);1H
• Clé InChI: PJJJBBJSCAKJQF-UHFFFAOYSA-N

Description

Description générale

A powerful protein denaturant that is widely used in the purification of proteins, nucleic acids, and mRNA. It is used in a variety of applications, including sequencing, molecular weight determinations, and as a solubilizing agent for electrophoresis.

Absorbance (6.0 M, H₂O): <0.2 at 230 nm; <0.03 at 260 nm.

Application

• Revealing the Roles of Guanidine Hydrochloride Ionic Liquid in Ion Inhibition and Defects Passivation for Efficient and Stable Perovskites Solar Cells: Discusses how guanidine hydrochloride ionic liquid enhances the efficiency and stability of perovskite solar cells by ion inhibition and defect passivation (Saeed A et al., 2024).


• N-Fluorosulfonyl Guanidine: An Entry to N-Guanyl Sulfamides and Sulfamates: Investigates the use of N-fluorosulfonyl guanidine for synthesizing N-guanyl sulfamides and sulfamates, showcasing its potential in chemical synthesis and material science (Wang W et al., 2024).


• Efficient extraction of lignin from moso bamboo by microwave-assisted ternary deep eutectic solvent pretreatment for enhanced enzymatic hydrolysis: Explores the role of guanidine hydrochloride in enhancing the enzymatic hydrolysis of lignin extracted from moso bamboo using a microwave-assisted deep eutectic solvent method (Feng Y et al., 2024).


• Computational Enzyme Redesign Enhances Tolerance to Denaturants for Peptide C-Terminal Amidation: Details how computational redesign of enzymes, involving guanidine hydrochloride, can enhance their tolerance to denaturants, improving the efficiency of peptide C-terminal amidation processes (Zhu T et al., 2024).


• Parasite Burden of Trypanosoma cruzi in Whole Blood and Buffy Coat Determined by Real-Time PCR in Individuals with Chronic Chagas Disease: Describes the use of guanidine hydrochloride in real-time PCR processes to quantify the parasite burden in blood samples from individuals with Chagas disease, demonstrating its utility in enhancing diagnostic assays (Liempi D et al., 2024).

Avertissement

Toxicity: Harmful (C)

Autres remarques

Bastiras, S., and Wallace, J.C. 1992. Biochemistry31, 9304.
Plaza del Pino, I.M., et al. 1992. Biochemistry31, 11196.
Steinman, H., et al. 1974. J. Biol. Chem.249, 7326.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

ULTROL is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302 + H332,H315,H319
• Conseils de prudence: P261 - P264 - P301 + P312 - P302 + P352 - P304 + P340 + P312 - P305 + P351 + P338
• Classification des risques: Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable