3541

Glutathione, Reduced, Free Acid

>98% (titration), solid, endogenous antioxidant, Calbiochem^®

• Synonyme(s) : Glutathione, Reduced, Free Acid, γ-Glu-Cys-Gly, GSH
• Formule empirique (notation de Hill): C₁₀H₁₇N₃O₆S
• Numéro CAS: 70-18-8
• Poids moléculaire : 307.32
• Numéro MDL: MFCD00065939
• Code UNSPSC : 12352209
• Nomenclature NACRES : NA.25

Propriétés

• product name: Glutathione, Reduced, Free Acid, Glutathione, Reduced, Free Acid, CAS 70-18-8, is a tripeptide that serves as an endogenous antioxidant and provides protection against auto-oxidation.
• Niveau de qualité: 200
• Pureté: >98% (titration)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic)
• Couleur: white
• Solubilité: water: 1 mg/mL; DMF: 10 mg/mL; ethanol: 5 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• InChI: 1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)
• Clé InChI: RWSXRVCMGQZWBV-UHFFFAOYSA-N

Description

Description générale

Glutathione is a tripeptide composed of cysteine, glycine, and glutamic acid. In cells glutathione either exists as reduced (GSH) and oxidized (GSSG). The ratio of glutathione reduced (GSH) to glutathione oxidized (GSSG) determines the cell’s redox status. Healthy resting cells have a GSH/GSSG ratio >100. In cells under oxidative stress, the GSH/GSSG ratio drops to between 1 and 10. Glutathione has also been identified as the thiol buffer that keeps sulfohydryl groups in the reduced form of many proteins. It is produced solely in the cytochrome P450 system and actively pumped to mitochondria. GSH depletion can lead to Neurodegenerative disorders, Pulmonary disease, Immune diseases, Cardiovascular diseases, Chronic age-related diseases, Liver disease, Cystic fibrosis and Aging process itself.

Application

Glutathione, Reduced, Free Acid has been used to elute the GST-OTUD6A proteins after purification using Glutathione Sepharose.

Actions biochimiques/physiologiques

Cell permeable: no

Product does not compete with ATP.

Reversible: no

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable