341576-M

Fibrinogen, Human Plasma

Fibrinogen, CAS 9001-32-5, is a soluble plasma glycoprotein that is synthesized in the hepatic parenchymal cells. Contains >90% clottable protein.

• Synonyme(s) : Fibrinogen, Human Plasma, Coagulation Factor I
• Numéro CAS: 9001-32-5
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.25

Propriétés

• Source biologique: human plasma
• Niveau de qualité: 100
• Forme: lyophilized
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Solubilité: sterile distilled water: soluble
• Température de stockage: 2-8°C

Description

Description générale

Do not disturb until the fibrinogen is completely solubilized.

Native fibrinogen from human plasma. A plasma glycoprotein, essential for clotting blood. Synthesized and secreted by hepatic parenchymal cells. Fibrinogen, also known as Coagulation Factor I, is an acute-phase plasma protein found at a concentration of about 300 mg/100 ml. Conversion of soluble fibrinogen to the insoluble clot-forming fibrin is the terminal stage of blood clotting. Clinically, fibrinogen is found at elevated levels during pregnancy, after surgical trauma, or in cases of myocardial infarction, and is decreased in cases of liver cirrhosis and serum hepatitis.

Native fibrinogen from human plasma. A plasma glycoprotein, essential for clotting of blood, synthesized and secreted by hepatic parenchymal cells. Contains ≥ 90% clottable proteins.

Actions biochimiques/physiologiques

Contains ≥90% clottable proteins.

Avertissement

Toxicity: Harmful (C)

Forme physique

Lyophilized from 20 mM sodium citrate-HCl, pH 7.4.

Notes préparatoires

Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitution

Following reconstitution, aliquot and freeze (-70°C). Do not store solutions on ice; precipitation will occur. Stock solutions are stable for up to 6 months at -70°C. Avoid freeze-thaw cycles.

Protein must be thawed in a 37°C water bath. Solutions used to reconstitute fibrinogen should first be brought to 37°C. Once at 37°C, the solution can be added to the fibrinogen and this mixture should remain at 37°C until the fibrinogen is completely solubilized. If the vial is disturbed before the fibrinogen is completely dissolved, the fibrinogen will precipitate. Please see vial label for lot-specific reconstitution volume.

Remarque sur l'analyse

homogeneous by SDS-PAGE.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Ce produit, destiné à la recherche scientifique, est soumis à une réglementation spécifique en France, y compris pour les activités d′importation et d′exportation (Article L 1211-1 alinéa 2 du Code de la Santé Publique). L′acheteur (c′est-à-dire l′utilisateur FINAL) est tenu d′obtenir une autorisation d′importation auprès du ministère français de la recherche, mentionné à l′article L1245-5-1 II du Code de la Santé Publique. En commandant ce produit, vous confirmez détenir l′autorisation d′importation requise.

Informations sur la sécurité

• Code de la classe de stockage: 13 - Non Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3