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Merck
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Key Documents

07-843

Sigma-Aldrich

Anti-phospho-IRS1 (Ser616) Antibody

Upstate®, from rabbit

Synonyme(s) :

IRS-1, Insulin Receptor Substrate 1

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Forme d'anticorps

affinity purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

polyclonal

Produit purifié par

affinity chromatography

Espèces réactives

human

Fabricant/nom de marque

Upstate®

Technique(s)

immunocytochemistry: suitable
western blot: suitable

Isotype

IgG

Numéro d'accès NCBI

NM_000208.2
NM_001079817.1

Numéro d'accès UniProt

P06213

Conditions d'expédition

dry ice

Modification post-traductionnelle de la cible

phosphorylation (pSer616)

Informations sur le gène

human ... INSR(3643)

Spécificité

Human IRS1 (Insulin Receptor Substrate 1) phosphorylated on Serine residue 616. Sequence 100% homologous with mouse, rat, and pig.
Predicted to cross-react with mouse and rat based on 100% sequence homology, but have not been tested.

Immunogène

Peptide corresponding to amino acid region encompassing the human, mouse, and rat phospho-IRS-1 (Ser616)

Application

Immunoblot Analysis: 0.5 μg/mL dilutions of this antibody detected phospho-IRS1 (Ser616) in RIPA lysates from TPA treated CHO cells transfected with human IRS1.
Research Category
Signaling
Research Sub Category
Insulin/Energy Signaling
anti-phospho-IRS1 (Ser616) Antibody is an antibody against phospho-IRS1 (Ser616) for use in IC & WB.

Qualité

Evaluated by immunoblot.

Description de la cible

165 kDa

Forme physique

100 μL of affinity purified rabbit polyclonal IgG in PBS (without Mg2+ and Ca2+), pH 7.3, containing 1.0 mg/mL BSA (IgG, protease free), 0.05% sodium azide and 50% glycerol.
Affinity purified

Stockage et stabilité

1 year at -20°C.
Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/ thaw cycles, which may damage IgG and affect product performance.

Informations légales

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Mei-Hsin Hsu et al.
Neuroreport, 31(3), 265-273 (2020-02-08)
This study aimed to examine the combined effects of prenatal glucocorticoid exposure and a postnatal high-fat diet (HFD) on offspring brain development and metabolic disturbance. Besides, the effects of an enriched environment were assessed. Pregnant Sprague-Dawley rats were administered vehicle
Mei-Hsin Hsu et al.
International journal of molecular sciences, 21(10) (2020-05-16)
To examine the effects of maternal resveratrol in rats borne to dams with gestational high-fat diet (HFD)/obesity with or without postnatal high-fat diet. We first tested the effects of maternal resveratrol intake on placenta and male fetus brain in rats
M Zulema Cabail et al.
Nature communications, 6, 6406-6406 (2015-03-12)
The insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF1R) are highly related receptor tyrosine kinases with a disulfide-linked homodimeric architecture. Ligand binding to the receptor ectodomain triggers tyrosine autophosphorylation of the cytoplasmic domains, which stimulates catalytic activity and creates

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