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Merck
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Principaux documents

07-539

Sigma-Aldrich

Anti-acetyl-Histone H3 (Lys 4) Antibody

Upstate®, from rabbit

Synonyme(s) :

H3K4Ac, Histone H3 (acetyl K4)

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Produit purifié par

affinity chromatography

Espèces réactives

human

Fabricant/nom de marque

Upstate®

Technique(s)

ChIP: suitable (ChIP-seq)
dot blot: suitable
inhibition assay: suitable (peptide)
multiplexing: suitable
western blot: suitable

Isotype

IgG

Numéro d'accès NCBI

NP_003484

Numéro d'accès UniProt

Q16695

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

acetylation (Lys 4)

Informations sur le gène

human ... H3F3B(3021)

Spécificité

Broad species cross reactivity is expected
Histone H3 when acetylated on Lys4

Immunogène

KLH-conjugated, synthetic peptide containing the sequence ...RT[AcK]Q... in which [AcK] corresponds to acetyl lysine 4 of human histone H3

Application

Suggested dilutions:
Western Blot: 1:1000 - 1:10,000
Anti-acetyl-Histone H3 (Lys 4) Antibody is a rabbit polyclonal antibody for detection of acetyl-Histone H3 (Lys 4) also known as H3K4Ac, Histone H3 (acetyl K4) & has been validated in Mplex, WB, PIA, ChIP, ChIP-seq, DB.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Histones

Qualité

Routinely evaluated by immunoblot.

Description de la cible

Mr ~17kDa

Forme physique

100μl of immunoaffinity purified rabbit IgG in a buffer with 0.1M Tris-glycine, pH 7.4 and 0.15M NaCl, and containing 0.05% sodium azide and 30% glycerol
ImmunoAffinity Purified

Stockage et stabilité

1 year at -20°C from date of shipment

Informations légales

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Federico Forneris et al.
The Journal of biological chemistry, 281(46), 35289-35295 (2006-09-22)
Human lysine-specific demethylase (LSD1) is a chromatin-modifying enzyme that specifically removes methyl groups from mono- and dimethylated Lys4 of histone H3 (H3-K4). We used a combination of in vivo and in vitro experiments to characterize the substrate specificity and recognition
Flore Beurton et al.
Nucleic acids research, 47(21), 11164-11180 (2019-10-12)
The CFP1 CXXC zinc finger protein targets the SET1/COMPASS complex to non-methylated CpG rich promoters to implement tri-methylation of histone H3 Lys4 (H3K4me3). Although H3K4me3 is widely associated with gene expression, the effects of CFP1 loss vary, suggesting additional chromatin
Oral administration of the pimelic diphenylamide HDAC inhibitor HDACi 4b is unsuitable for chronic inhibition of HDAC activity in the CNS in vivo.
Beconi, M; Aziz, O; Matthews, K; Moumne, L; O'Connell, C; Yates, D; Clifton, S; Pett et al.
Testing null
Ya-Wei Chen et al.
Cancer, 119(24), 4259-4267 (2013-12-05)
Patterns of global histone modifications have been suggested to be predictors of clinical outcome in many cancers. However, the role of global histone modification patterns in oral squamous cell carcinoma (OSCC) is unclear. A retrospective clinicopathologic analysis was undertaken of
Runsheng He et al.
Nucleic acids research, 45(11), 6427-6441 (2017-04-13)
Epigenetic regulation of chromatin plays a critical role in controlling embryonic stem (ES) cell self-renewal and pluripotency. However, the roles of histone demethylases and activating histone modifications such as trimethylated histone 3 lysine 4 (H3K4me3) in transcriptional events such as
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