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Merck
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Key Documents

06-1385

Sigma-Aldrich

Anti-PDX1 (goat) Antibody

serum, from goat

Synonyme(s) :

pancreatic and duodenal homeobox 1, pancreatic-duodenal homeobox factor 1, somatostatin transcription factor 1, insulin promoter factor 1, homeodomain transcription factor, Insulin promoter factor 1, Somatostatin-transactivating factor 1, Insulin upstrea

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

goat

Niveau de qualité

100

Forme d'anticorps

serum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Espèces réactives

human, mouse

Technique(s)

immunohistochemistry: suitable
western blot: suitable

Numéro d'accès NCBI

NP_032840

Numéro d'accès UniProt

P52946

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

mouse ... Pdx1(18609)

Description générale

Transcription factor PDX1, also known as pancreatic and duodenal homeobox 1, activates expression of the insulin and somatostatin genes. This protein is a key regulator of islet peptide hormone expression and also plays an essential role in pancreatic development. It has been shown to interact with the basic helix-loop-helix domains of TCF3(E47) and NEUROD1 and with HMG-I(Y). This protein also interacts with the methyltransferase SETD7. Mutations in this gene may be involved in several disorders of the pancreas or in diabetes mellitus.

Immunogène

Recombinant protein corresponding to the N-terminus of mouse PDX1.

Application

Anti-PDX1 (goat) Antibody is a Goat Polyclonal Antibody for detection of PDX1 also known as pancreatic & duodenal homeobox 1, somatostatin transcription factor 1, Insulin promoter factor 1 & has been validated in WB & IHC.
Immunohistochemistry Analysis: 1:400 dilution from a represenative lot detected PDX1 in normal human pancreas tissue.

Qualité

Evaluated by Western Blot in mouse pancreatic β T-cell lysate.

Western Blot Analysis: 1:1,000 dilution of this antibody detected PDX1 on 10 µg of mouse pancreatic β T-cell lysate.

Description de la cible

~ 39 kDa

Forme physique

Unpurified goat polyclonal serum containing 0.05% sodium azide.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Romina J Bevacqua et al.
Nature communications, 12(1), 2397-2397 (2021-04-25)
Gene targeting studies in primary human islets could advance our understanding of mechanisms driving diabetes pathogenesis. Here, we demonstrate successful genome editing in primary human islets using clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated protein 9 (Cas9). CRISPR-based
Signaling pathways for sphingosylphosphorylcholine-mediated mitogenesis in Swiss 3T3 fibroblasts.
N N Desai,R O Carlson,M E Mattie,A Olivera,N E Buckley,T Seki,G Brooker,S Spiegel
The Journal of cell biology null
Giannicola Genovese et al.
Nature, 542(7641), 362-366 (2017-02-09)
Malignant neoplasms evolve in response to changes in oncogenic signalling. Cancer cell plasticity in response to evolutionary pressures is fundamental to tumour progression and the development of therapeutic resistance. Here we determine the molecular and cellular mechanisms of cancer cell
Pauline Jeannot et al.
Oncotarget, 6(34), 35880-35892 (2015-09-30)
p27Kip1 (p27) is a negative regulator of proliferation and a tumor suppressor via the inhibition of cyclin-CDK activity in the nucleus. p27 is also involved in the regulation of other cellular processes, including transcription by acting as a transcriptional co-repressor.

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