05-801
Anti-trimethyl-Histone H3 (Lys36) Antibody, clone MC86, rabbit monoclonal
clone MC86, Upstate®, from rabbit
Synonyme(s) :
H3K36me3, Histone H3 (tri methyl K36)
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Forme d'anticorps
purified immunoglobulin
Type de produit anticorps
primary antibodies
Clone
MC86, monoclonal
Espèces réactives
chicken
Fabricant/nom de marque
Upstate®
Technique(s)
ChIP: suitable
dot blot: suitable
inhibition assay: suitable (peptide)
western blot: suitable
Isotype
IgG
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Modification post-traductionnelle de la cible
trimethylation (Lys36)
Spécificité
Broad species cross-reactivity is expected.
Recognizes Histone H3 trimethylated on Lysine 36.
Immunogène
peptide containing the sequence GVme3KKP, in which me3K corresponds to trimethyl lysine 36 of human histone H3
Application
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Histones
Histones
Use Anti-trimethyl-Histone H3 (Lys36) Antibody, clone MC86 (rabbit monoclonal antibody) validated in DB, WB, PIA to detect trimethyl-Histone H3 (Lys36) also known as H3K36me3, Histone H3 (tri methyl K36).
Qualité
routinely evaluated by immunoblot on chicken Core Histones (Catalog #13-107); did not detect unmodified recombinant Histone H3 (Catalog #14-411)
Description de la cible
~17 kDa
Forme physique
Format: Purified
Protein A Purified immunoglobulin in a solution containing 0.07M Tris-glycine, 0.105M NaCl, pH 7.4, 0.035% sodium azide, 30% glycerol.
Protein A purified
Stockage et stabilité
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Remarque sur l'analyse
Control
Acid extracted proteins from HeLa cells
Acid extracted proteins from HeLa cells
Autres remarques
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Informations légales
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Jian Zhang et al.
The Plant journal : for cell and molecular biology, 64(4), 604-617 (2010-09-09)
MADS-box transcription factors are known for their roles in plant growth and development. The regulatory mechanisms of spatial and temporal specific expression of MADS-box genes and the function of MADS-box genes in other biological processes are still to be explored.
The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation.
Yoh, SM; Lucas, JS; Jones, KA
Genes & Development null
Mass spectrometry analysis of the variants of histone H3 and H4 of soybean and their post-translational modifications.
Wu, T; Yuan, T; Tsai, SN; Wang, C; Sun, SM; Lam, HM; Ngai, SM
BMC plant biology null
Jun Wang et al.
Nature plants, 6(7), 823-837 (2020-06-24)
Histone demethylation is crucial for proper chromatin structure and to ensure normal development, and requires the large family of Jumonji C (JmjC)-containing demethylases; however, the molecular mechanisms that regulate the substrate specificity of these JmjC-containing demethylases remain largely unknown. Here
Li-Qun Chen et al.
Plant physiology, 174(3), 1795-1806 (2017-05-28)
Methylation of Lys residues in the tail of the H3 histone is a key regulator of chromatin state and gene expression, conferred by a large family of enzymes containing an evolutionarily conserved SET domain. One of the main types of
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