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Merck
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Key Documents

05-435

Sigma-Aldrich

Anti-Lck Antibody, clone 3A5

clone 3A5, Upstate®, from mouse

Synonyme(s) :

Anti-IMD22, Anti-LSK, Anti-YT16, Anti-p56lck, Anti-pp58lck

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

3A5, monoclonal

Espèces réactives

mouse, human, rat

Fabricant/nom de marque

Upstate®

Technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

Isotype

IgG2bκ

Numéro d'accès NCBI

NM_005356

Numéro d'accès UniProt

P06239

Conditions d'expédition

dry ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... LCK(3932)

Spécificité

Recognizes Lck.

Immunogène

GST-fusion to residues 1-225 of murine Lck

Application

Research Category
Signaling
Research Sub Category
Immunological Signaling
This Anti-Lck Antibody, clone 3A5 is validated for use in IP, WB for the detection of Lck.

Qualité

routinely evaluated by immunoblot on RIPA lysates from Jurkat cells

Description de la cible

56 kDa

Liaison

Replaces: 04-372

Forme physique

Format: Purified
Protein A purified
Protein A purified antibody in 100uL of 10mM PBS, pH 7.4

Stockage et stabilité

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Remarque sur l'analyse

Control
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informations légales

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

The differential expression of LCK and BAFF-receptor and their role in apoptosis in human lymphomas.
Jennifer C Paterson, Sara Tedoldi, Andrew Craxton, Margaret Jones, Martin-Leo Hansmann et al.
Haematologica null
Tiphaine Douanne et al.
Open biology, 14(2), 230456-230456 (2024-02-28)
Cytotoxic T lymphocytes (CTLs) are key effectors of the adaptive immune system that recognize and eliminate virally infected and cancerous cells. In naive CD8+ T cells, T-cell receptor (TCR) engagement drives a number of transcriptional, translational and proliferation changes over
Association of SRC-related kinase Lyn with the interleukin-2 receptor and its role in maintaining constitutive phosphorylation of JAK/STAT in human T-cell leukemia virus type 1-transformed T cells.
Shuh, M; Morse, BA; Heidecker, G; Derse, D
Journal of virology null
B Omri et al.
Journal of neurochemistry, 67(4), 1360-1364 (1996-10-01)
The lck gene product, p56lck, is a member of the src-related family of protein tyrosine kinases. It is known as lymphocyte specific and involved in thymocyte development and in the immune response mediated by the T cell receptor. We report
Jing Jin et al.
Molecular and cellular biology, 36(6), 1007-1018 (2016-01-13)
The heat shock protein 90 (HSP90) and cell division cycle 37 (CDC37) chaperones are key regulators of protein kinase folding and maturation. Recent evidence suggests that thermodynamic properties of kinases, rather than primary sequences, are recognized by the chaperones. In
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