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Merck
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Key Documents

05-1066

Sigma-Aldrich

Anti-Insulin Antibody, clone E11D7

clone E11D7, from mouse

Synonyme(s) :

Anti-IDDM, Anti-IDDM1, Anti-IDDM2, Anti-ILPR, Anti-IRDN, Anti-MODY10, Anti-PNDM4

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100

Forme d'anticorps

purified antibody

Type de produit anticorps

primary antibodies

Clone

E11D7, monoclonal

Espèces réactives

human

Réactivité de l'espèce (prédite par homologie)

rat, mouse

Conditionnement

antibody small pack of 25 μg

Technique(s)

ELISA: suitable
immunohistochemistry: suitable (paraffin)

Isotype

IgG1κ

Numéro d'accès NCBI

NM_000207.2

Numéro d'accès UniProt

P01308

Conditions d'expédition

ambient

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... INS(3630)
mouse ... Ins1(16333)
rat ... Ins1(24505)

Catégories apparentées

Description générale

Insulin is a polypeptide hormone that regulates carbohydrate metabolism. Apart from being the primary agent in carbohydrate homeostasis, it has effects on fat metabolism.

Spécificité

Recognizes insulin

Immunogène

Epitope: Insulin
Human recombinant Insulin

Application

Anti-Insulin Antibody, clone E11D7 detects level of Insulin & has been published & validated for use in ELISA, IH(P).
ELISA (Direct) Analysis:
Insulin-coated plate was incubated with Anti-Insulin, clone E11D7 in 2-fold serial dilutions diluted in PBST from 5 μg/mL to 0.01 μg/mL.
Research Category
Signaling

Metabolism
Research Sub Category
Insulin/Energy Signaling

Glucose/Glycogen Metabolism

Metabolic Hormones & Receptors

Qualité

Immunohistochemistry Analysis:
20 μg/mL of this antibody detected insulin in β cells.

Description de la cible

6 kDa

Forme physique

Format: Purified
Protein G Purified
Purified mouse monolconal IgG1κ in 0.1M Tris-Glycine (pH7.4), 150mM NaCl with 0.05%NaN3

Stockage et stabilité

Stable for 1 year at 2-8ºC from date of receipt.

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Réf. du produit
Description
Tarif

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Yoshimitsu Taguchi et al.
The Journal of biological chemistry, 291(23), 12029-12038 (2016-04-10)
Sphingosine-1-phosphate (S1P) is a sphingolipid metabolite that regulates basic cell functions through metabolic and signaling pathways. Intracellular metabolism of S1P is controlled, in part, by two homologous S1P phosphatases (SPPases), 1 and 2, which are encoded by the Sgpp1 and
Mi Ran Choi et al.
Journal of ginseng research, 41(4), 503-512 (2017-10-13)
Chronic heavy alcohol consumption may raise the risk of developing type 2 diabetes mellitus. Saponins inhibit apoptosis of pancreatic islet cells and reduce lipid parameters. The present study was designed to investigate the effect of saponin on chronic ethanol-treated diabetic
Gabriel Cao et al.
PloS one, 16(6), e0243340-e0243340 (2021-06-12)
The objective of this work was to analyze the structural changes of the pancreatic islets in rats, after 6 month consuming regular and light cola for 6 months. Also, we have analyzed the possible role of PDX-1 in that process.
Activation of PPAR? up-regulates the expression of insulin gene transcription factor MafA and ameliorates glucose-induced insulin secretion impaired by palmitate.
Mingming Cao,Yang Long,Yuzhen Tong,Jun Wan,Nanwei Tong
Molecular and Cellular Biochemistry null
Daniel Neumeier et al.
European journal of immunology, 52(2), 297-311 (2021-11-03)
Plasma cells and their secreted antibodies play a central role in the long-term protection against chronic viral infection. However, due to experimental limitations, a comprehensive description of linked genotypic, phenotypic, and antibody repertoire features of plasma cells (gene expression, clonal
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