04-1573

Anti-Ataxin-7 Antibody, clone 3SCA-1C1

ascites fluid, clone 3SCA-1C1, from mouse

• Synonyme(s) : ADCAII, OPCA3, SCA7
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Niveau de qualité: 100
• Forme d'anticorps: ascites fluid
• Type de produit anticorps: primary antibodies
• Clone: 3SCA-1C1, monoclonal
• Espèces réactives: rat, mouse
• Réactivité de l'espèce (prédite par homologie): human (immunogen homology)
• Technique(s): western blot: suitable
• Isotype: IgG1κ
• Numéro d'accès NCBI: NP_000324
• Numéro d'accès UniProt: O15265
• Conditions d'expédition: dry ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... ATXN7(6314)

Description

Description générale

Ataxin-7 is a protein of unknown function. However, since this protein contains a nuclear localization sequence and is found to be localized in the nucleus, it has been postulated to be a potential transcription factor. Spinocerebellar ataxia-7 (one of a group of hereditary neurodegenrative diseases) is caused by an expanded CAG repeat in the gene encoding ataxin-7 (the diseased allele associated with Spinocerebellar ataxia-7, contains 38-130 CAG repeats (near the N-terminus), compared to 7-17 in the normal allele). In cells where there is a mutation of the SCA7 gene, ataxin-7 accumulates in intranuclear inclusions and can result in cell death. Spinocerebellar ataxia (SCA) is one of a group of genetic disorders characterized by slowly progressive incoordination of gait and often associated with poor coordination of hands, speech, and eye movements. Frequently, atrophy of the cerebellum occurs.

Spécificité

This antibody recognizes Ataxin-7 protein.

Immunogène

Epitope: Epitope mapped between aa 66 and aa 119.

Recombinant human Ataxin 7 as a fusion protein (aa 1 to aa 229).

Application

Anti-Ataxin-7 Antibody, clone 3SCA-1C1 is an antibody against Ataxin-7 for use in WB.

ELISA: A 1:500-1:5,000 dilution of a previous lot of 04-1573 was used in ELISA, as reported by an outside laboratory. Immunocytochemistry: A 1:500-1:5,000 dilution of a previous lot of 04-1573 was used in IC, as reported by an outside laboratory.

Research Category
Neuroscience

Neuroscience

Research Sub Category
Signaling Neuroscience

Neurodegenerative Diseases

Qualité

Evaluated by Western Blotting of Rat brain lysate. Western Blotting: Representative lot data: A 1:1000 dilution of this antibody detected Ataxin-7 in 10ug of Rat brain tissue lysate.

Description de la cible

96 kDa Calculated

Forme physique

Unpurified

Unpurified mouse IgG1, k antibody in ascites fluid without preservatives.

Stockage et stabilité

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Remarque sur l'analyse

Control
Rat brain tissue lysate.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): nwg
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable