P-151

PEth 16:0/18:1-D₅ solution

100 μg/mL in methanol (as free phosphate), certified reference material, ampule of 1 mL, Cerilliant^®

• Formule empirique (notation de Hill): C₃₉H₆₉D₅O₈P · NC₃H₁₀
• Poids moléculaire : 767.12
• Code UNSPSC : 41116107
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: certified reference material
• Niveau de qualité: 300
• Forme: liquid
• Caractéristiques: Snap-N-Spike^®/Snap-N-Shoot^®
• Conditionnement: ampule of 1 mL
• Fabricant/nom de marque: Cerilliant^®
• Concentration: 100 μg/mL in methanol (as free phosphate)
• Technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Application(s): forensics and toxicology
• Format: single component solution
• Température de stockage: −70°C

Description

Description générale

This stable-labeled internal standard is suitable for quantitation of PEth 16:0/18:1 in LC/MS or GC/MS applications. PEth 16:0/18:1, also known as phosphatidylethanol 16:0/18:1, is a sensitive and specific biomarker for alcohol use and abuse. Since the detection window of PEth 16:0/18:1 in blood is longer than that of ethyl glucuronide (EtG) or ethyl sulfate (EtS) in urine, measurement of blood PEth 16:0/18:1 level is routinely performed in clinical toxicology and forensic testing applications such as abstinence monitoring and workplace drug testing. PEth 16:0/18:1 has also been investigated as a biomarker to confirm prenatal alcohol exposure (PAE).

Application

• Validation of LC-MS/MS method for erythrocyte phosphatidylethanol: A recent study validated a liquid chromatography tandem mass spectrometry method for erythrocyte phosphatidylethanol (PEth), utilizing the PEth 16:0/18:1-D₅ internal standard. This research highlights critical considerations for using PEth as a reliable clinical biomarker of alcohol consumption, proving essential for advancements in biochemical research reagents and methodology (White et al., 2022).

Informations légales

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS02,GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H225,H301 + H311 + H331,H370
• Conseils de prudence: P210 - P260 - P280 - P301 + P310 + P330 - P308 + P311 - P370 + P378 - P403 + P233
• Classification des risques: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Organes cibles: Eyes
• Code de la classe de stockage: 3 - Flammable liquids
• Point d'éclair (°F): 49.5 °F - closed cup
• Point d'éclair (°C): 9.7 °C - closed cup